Glutathione S-transferase, incense burning and asthma in children

被引：47

作者：

Wang, I-J. ^{[3
,5
,6
]}

Tsai, C-H. ^{[1
]}

Chen, C-H. ^{[4
]}

Tung, K-Y. ^{[1
]}

Lee, Y. L. ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Res Ctr Genes Environm & Human Hlth, Coll Publ Hlth, Taipei 100, Taiwan

[3] China Med Univ, Coll Publ Hlth, Taichung, Taiwan

[4] Hualien Cty Hlth Bur, Guangfu Township Hlth Off, Hualien, Taiwan

[5] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan

[6] Taipei Hosp, Dept Paediat, Dept Hlth, Taipei, Taiwan

来源：

EUROPEAN RESPIRATORY JOURNAL | 2011年 / 37卷 / 06期

关键词：

Asthma; gene-environment interaction; GSTT1; incense burning; RESPIRATORY HEALTH; OXIDATIVE STRESS; IMMUNOGLOBULIN-E; AIR-POLLUTION; RISK; POLYMORPHISMS; ASSOCIATION; SYMPTOMS; GENES; METAANALYSIS;

D O I：

10.1183/09031936.00137210

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Incense burning is a popular practice in many family homes and temples. However, little is known about the effects of indoor incense burning and genetic polymorphisms on asthma. This study evaluated the effects of indoor incense burning and glutathione S-transferase (GST) genetic polymorphisms on asthma and wheeze. In 2007, 3,764 seventh-grade schoolchildren (mean +/- SD age 12.42 +/- 0.65 yrs) were evaluated using a standard questionnaire for information about respiratory symptoms and environmental exposures. Multiple logistic regressions were performed to assess the association between GST polymorphisms and incense burning frequency on asthma and wheeze, after adjusting for potential confounders. The frequency of incense burning at home was associated with increased risk of current asthma (p=0.05), medication use (p=0.03) and exercise wheeze (p=0.001). GSTh1 (GSTT1) null genotypes were associated with current asthma (OR 1.43, 95% CI 1.00-2.04) and medication use (OR 1.46, 95% CI 1.01-2.22). GSTT1 showed a significant interactive effect with incense burning on current asthma, current wheeze and nocturnal wheeze. The frequency of incense burning was associated with increased risk of current asthma, medication use, lifetime wheeze, nocturnal wheeze and exercise wheeze in an exposure-response manner among children with GSTT1 null genotype (p<0.05). Incense burning is a risk factor for asthma and wheezing, especially in GSTT1 genetically susceptible children.

引用

页码：1371 / 1377

页数：7

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