The additional value of PET/CT over PET in FDG imaging of oesophageal cancer

被引:96
作者
Bar-Shalom, R [1 ]
Guralnik, L
Tsalic, M
Leiderman, M
Frenkel, A
Gaitini, D
Ben-Nun, A
Keidar, Z
Israel, O
机构
[1] Rambam Med Ctr, Dept Nucl Med, Haifa, Israel
[2] Rambam Med Ctr, Dept Diagnost Imaging, Haifa, Israel
[3] Rambam Med Ctr, Dept Oncol, Haifa, Israel
[4] Technion Israel Inst Technol, Sch Med, Haifa, Israel
[5] Rambam Med Ctr, Dept Thorac Med, Haifa, Israel
关键词
D O I
10.1007/s00259-005-1795-y
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The aim of this study was to assess the value of combined PET/CT compared with PET reviewed side-by-side with CT, in patients with oesophageal cancer, before and after surgery. Methods: Forty-one FDG PET/CT studies were performed in 32 patients with oesophageal cancer, before surgery (n=18) or during follow-up after resection of the primary tumour (n=23). One hundred and fifteen sites suspicious for malignancy were evaluated. PET/CT was prospectively compared with PET reviewed side-by-side with CT, for detection, accurate localisation and characterisation of malignant sites. PET/CT performance in different anatomical regions was compared before and after surgery. The impact of fused data on patient management was retrospectively assessed. Results: PET/CT had an incremental value over PET for interpretation of 25 of 115 sites (22%), changing the initial characterisation of ten sites to either malignant (n=1) or benign (n=9), and defining the precise anatomical location of 15 sites. PET/CT provided better specificity and accuracy than PET for detecting sites of oesophageal cancer (81% and 90% vs 59% and 83% respectively, p < 0.01). Fusion was of special value for interpretation of cervical and abdomino-pelvic sites, for disease assessment in loco-regional lymph nodes before surgery and in regions of postoperative anatomical distortion. PET/CT had an impact on the further management of four patients (10%), by detecting nodal metastases that warranted disease upstaging (n=2) and by excluding disease in sites of benign uptake after surgery (n=2). Conclusion: PET/CT improves the accuracy of FDG imaging in oesophageal cancer and provides data of diagnostic and therapeutic significance for further patient management.
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页码:918 / 924
页数:7
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