Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

被引：29

作者：

Vianello, M ^{[1
]}

Tavolato, B ^{[1
]}

Armani, M ^{[1
]}

Giometto, B ^{[1
]}

机构：

[1] Univ Padua, Dept Neurol & Psychiat Sci, Clin 2, I-35137 Padua, Italy

来源：

CEREBELLUM | 2003年 / 2卷 / 01期

关键词：

cerebellar ataxia; GAD antibodies; autoimmunity;

D O I：

10.1080/14734220309432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid. (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.

引用

页码：77 / 79

页数：3

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