Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

被引：29

作者：

Vianello, M ^{[1
]}

Tavolato, B ^{[1
]}

Armani, M ^{[1
]}

Giometto, B ^{[1
]}

机构：

[1] Univ Padua, Dept Neurol & Psychiat Sci, Clin 2, I-35137 Padua, Italy

来源：

CEREBELLUM | 2003年 / 2卷 / 01期

关键词：

cerebellar ataxia; GAD antibodies; autoimmunity;

D O I：

10.1080/14734220309432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid. (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.

引用

页码：77 / 79

页数：3

共 50 条

[21] Clinical features and immunotherapy outcomes of anti-glutamic acid decarboxylase 65 antibody-associated neurological disorders
Li Chengyu
Shi Weixiong
Chen Chao
Liu Songyan
Sang Lin
Zheng Zhong
Pan Hua
Jian Fan
Chen Na
Cui Tao
Wu Jianwei
Ren Haitao
Guan Hongzhi
Shao Xiaoqiu
JOURNAL OF NEUROIMMUNOLOGY, 2020, 345
[22] Disabling Central Paroxysmal Positioning Upbeat Nystagmus and Vertigo Associated With the Presence of Anti-Glutamic Acid Decarboxylase Antibodies
Martins, Ana I.
Carvalho, Joao N.
Amorim, Ana M.
Geraldo, Argemiro
Eggenberger, Eric
Lemos, Joao
JOURNAL OF NEURO-OPHTHALMOLOGY, 2018, 38 (01) : 32 - 35
[23] The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus
Liepert, Maryah
Alhaqqan, Shamayel
Husain, Alaa
Lochnan, Heather
Booth, Ronald A.
Shaw, Julie
Sun, Cathy J.
CLINICAL BIOCHEMISTRY, 2025, 135
[24] Serum titres of anti-glutamic acid decarboxylase-65 and anti-IA-2 autoantibodies are associated with different immunoregulatory milieu in newly diagnosed type 1 diabetes patients
Andrade Lima Gabbay, M.
Sato, M. N.
Duarte, A. J. S.
Dib, S. A.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2012, 168 (01) : 60 - 67
[25] Anti-Glutamic Acid Decarboxylase Encephalitis Presenting With Choreo-Dystonic Movements and Coexisting Electrographic Seizures
Kauppila, Linda Azevedo
Coelho, Miguel
Franco, Ana Catarina
Teodoro, Tiago
Peralta, Ana Rita
Bentes, Carla
Falcao, Filipa
Albuquerque, Luisa
MOVEMENT DISORDERS CLINICAL PRACTICE, 2019, 6 (06): : 483 - 485
[26] Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia
Takenoshita, H
Shizuka-Ikeda, M
Mitoma, H
Song, SY
Harigaya, Y
Igeta, Y
Yaguchi, M
Ishida, K
Shoji, M
Tanaka, M
Mizusawa, H
Okamoto, K
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (03) : 386 - 389
[27] Comparison of a new anti-glutamic acid decarboxylase (GAD) enzyme-linked immunosorbent assay (ELISA) with radioimmunoassay methods: A multicenter study
Wild, T
Scherbaum, WA
Gleichmann, H
Landt, M
Santiago, J
Endl, J
Landgraf, R
Cavallo, MG
Ganz, M
Pozzilli, P
HORMONE AND METABOLIC RESEARCH, 1997, 29 (08) : 403 - 406
[28] Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase
Hayakawa, N
Premawardhana, LDKE
Powell, M
Masuda, M
Arnold, C
Sanders, J
Evans, M
Chen, S
Jaume, JC
Baekkeskov, S
Smith, BR
Furmaniak, J
AUTOIMMUNITY, 2002, 35 (05) : 343 - 355
[29] The neurological syndromes associated with glutamic acid decarboxylase antibodies
Fidel Baizabal-Carvallo, Jose
JOURNAL OF AUTOIMMUNITY, 2019, 101 : 35 - 47
[30] Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity
Errichiello, Luca
Striano, Salvatore
Zara, Federico
Striano, Pasquale
NEUROLOGICAL SCIENCES, 2011, 32 (04) : 547 - 550

← 1 2 3 4 5 →