Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

被引：29
|
作者：
Vianello, M [1 ]
Tavolato, B [1 ]
Armani, M [1 ]
Giometto, B [1 ]
机构：
[1] Univ Padua, Dept Neurol & Psychiat Sci, Clin 2, I-35137 Padua, Italy
来源：
CEREBELLUM | 2003年 / 2卷 / 01期
关键词：
cerebellar ataxia; GAD antibodies; autoimmunity;
D O I：
10.1080/14734220309432
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid. (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.
引用
收藏
页码：77 / 79
页数：3
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