Engineering microbial factories for synthesis of value-added products

被引：171
作者：
Du, Jing [3 ]
Shao, Zengyi [3 ]
Zhao, Huimin [1 ,2 ,3 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Biochem, Inst Genom Biol, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA
来源：
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2011年 / 38卷 / 08期
基金：
美国国家科学基金会; 美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
Synthetic biology; Metabolic engineering; Microbial synthesis; Value-added products; Natural products; Fuels and chemicals; RECOMBINANT ESCHERICHIA-COLI; UTILIZING SACCHAROMYCES-CEREVISIAE; MYCOPLASMA-GENITALIUM GENOME; ANTIMALARIAL-DRUG PRECURSOR; SUCCINIC ACID PRODUCTION; COMBINATORIAL BIOSYNTHESIS; BENZYLISOQUINOLINE ALKALOIDS; 3-HYDROXYPROPIONIC ACID; POLYKETIDE BIOSYNTHESIS; SECONDARY METABOLITES;
D O I：
10.1007/s10295-011-0970-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.
引用
收藏
页码：873 / 890
页数：18
相关论文
共 146 条
[41]   Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome [J].
Gibson, Daniel G. ;
Glass, John I. ;
Lartigue, Carole ;
Noskov, Vladimir N. ;
Chuang, Ray-Yuan ;
Algire, Mikkel A. ;
Benders, Gwynedd A. ;
Montague, Michael G. ;
Ma, Li ;
Moodie, Monzia M. ;
Merryman, Chuck ;
Vashee, Sanjay ;
Krishnakumar, Radha ;
Assad-Garcia, Nacyra ;
Andrews-Pfannkoch, Cynthia ;
Denisova, Evgeniya A. ;
Young, Lei ;
Qi, Zhi-Qing ;
Segall-Shapiro, Thomas H. ;
Calvey, Christopher H. ;
Parmar, Prashanth P. ;
Hutchison, Clyde A., III ;
Smith, Hamilton O. ;
Venter, J. Craig .
SCIENCE, 2010, 329 (5987) :52-56
[42]   One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome [J].
Gibson, Daniel G. ;
Benders, Gwynedd A. ;
Axelrod, Kevin C. ;
Zaveri, Jayshree ;
Algire, Mikkel A. ;
Moodie, Monzia ;
Montague, Michael G. ;
Venter, J. Craig ;
Smith, Hamilton O. ;
Hutchison, Clyde A., III .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20404-20409
[43]   Gene array-based identification of changes that contribute to ethanol tolerance in ethanologenic Escherichia coli:: Comparison of KO11 (Parent) to LY01 (resistant mutant) [J].
Gonzalez, R ;
Tao, H ;
Purvis, JE ;
York, SW ;
Shanmugam, KT ;
Ingram, LO .
BIOTECHNOLOGY PROGRESS, 2003, 19 (02) :612-623
[44]  
Goodman Jordan., 2001, The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug
[45]  
Ha S.-J., 2010, Proc. Natl. Acad. Sci. U S A
[46]   Towards industrial pentose-fermenting yeast strains [J].
Hahn-Hagerdal, Barbel ;
Karhumaa, Kaisa ;
Fonseca, Cesar ;
Spencer-Martins, Isabel ;
Gorwa-Grauslund, Marie F. .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2007, 74 (05) :937-953
[47]   Engineered synthetic pathway for isopropanol production in Escherichia coli [J].
Hanai, T. ;
Atsumi, S. ;
Liao, J. C. .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (24) :7814-7818
[48]   Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae [J].
Hawkins, Kristy M. ;
Smolke, Christina D. .
NATURE CHEMICAL BIOLOGY, 2008, 4 (09) :564-573
[49]   Expression of a heterologous xylose transporter in a Saccharomyces cerevisiae strain engineered to utilize xylose improves aerobic xylose consumption [J].
Hector, Ronald E. ;
Qureshi, Nasib ;
Hughes, Stephen R. ;
Cotta, Michael A. .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 80 (04) :675-684
[50]   Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork [J].
Hertweck, Christian ;
Luzhetskyy, Andriy ;
Rebets, Yuri ;
Bechthold, Andreas .
NATURAL PRODUCT REPORTS, 2007, 24 (01) :162-190
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