SYNTHESIS OF CABOXAMYCIN AND ITS DERIVATIVES USING ECO-FRIENDLY OXIDATION

被引：7
|
作者：
Tagawa, Yoshinobu [1 ]
Koba, Hiroki [1 ]
Tomoike, Kazuhiro [1 ]
Sumoto, Kunihiro [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
来源：
HETEROCYCLES | 2011年 / 83卷 / 04期
关键词：
Caboxamycin; Activated Carbon; Molecular Oxygen; Benzoxazole; Eco-Friendly Oxidation;
D O I：
10.3987/COM-11-12138
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 3-hydroxyanthranilic acid or methyl 3-hydroxyanthranilate with O-benzylsalicylaldehyde in xylenes gave benzoxazole derivatives, which lead to a novel benzoxazole antibiotic, caboxamycin via debenzylation or demethylation in good yield, in the presence of dry activated carbon and bubbling molecular oxygen. The present reaction involves the simple procedure, easy workup and environmentally benign materials such as reusable activated carbon and molecular oxygen.
引用
收藏
页码：867 / 874
页数：8
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