Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

被引：114
|
作者：
Hranjec, Marijana [1 ]
Starcevic, Kristina [1 ]
Pavelic, Sandra Kraljevic [2 ]
Lucin, Pero [3 ]
Pavelic, Kresimir [2 ]
Karminski Zamola, Grace [1 ]
机构：
[1] Univ Zagreb, Fac Chem Engn & Technol, Dept Organ Chem, HR-10000 Zagreb, Croatia
[2] Univ Rijeka, Dept Biotechnol, HR-51000 Rijeka, Croatia
[3] Univ Rijeka, Sch Med, HR-51000 Rijeka, Croatia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 06期
关键词：
Benzimidazoles; Schiff bases; Antiproliferaive evaluation; UV/Vis and fluorescence spectroscopy; CRYSTAL-STRUCTURE DETERMINATION; ANTIMICROBIAL ACTIVITIES; ANTITUMOR EVALUATION; CORROSION-INHIBITORS; DERIVATIVES; COMPLEXES; DNA; POLYMERS; ACID;
D O I：
10.1016/j.ejmech.2011.03.008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by H-1 and C-13 NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2274 / 2279
页数：6
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