Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

被引：115

作者：

Hranjec, Marijana ^{[1
]}

Starcevic, Kristina ^{[1
]}

Pavelic, Sandra Kraljevic ^{[2
]}

Lucin, Pero ^{[3
]}

Pavelic, Kresimir ^{[2
]}

Karminski Zamola, Grace ^{[1
]}

机构：

[1] Univ Zagreb, Fac Chem Engn & Technol, Dept Organ Chem, HR-10000 Zagreb, Croatia

[2] Univ Rijeka, Dept Biotechnol, HR-51000 Rijeka, Croatia

[3] Univ Rijeka, Sch Med, HR-51000 Rijeka, Croatia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 06期

关键词：

Benzimidazoles; Schiff bases; Antiproliferaive evaluation; UV/Vis and fluorescence spectroscopy; CRYSTAL-STRUCTURE DETERMINATION; ANTIMICROBIAL ACTIVITIES; ANTITUMOR EVALUATION; CORROSION-INHIBITORS; DERIVATIVES; COMPLEXES; DNA; POLYMERS; ACID;

D O I：

10.1016/j.ejmech.2011.03.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by H-1 and C-13 NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well. (C) 2011 Elsevier Masson SAS. All rights reserved.

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页码：2274 / 2279

页数：6

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