New insights into lung development and diseases: the role of microRNAs

被引：15

作者：

Johar, Dina ^{[1
,2
]}

Siragam, Vinayakumar ^{[1
,2
]}

Mahood, Thomas H. ^{[1
,2
]}

Keijzer, Richard ^{[1
,2
]}

机构：

[1] Univ Manitoba, Div Pediat Surg Pediat & Child Hlth & Physiol, Dept Surg, Winnipeg, MB R3E 3P4, Canada

[2] Manitoba Inst Child Hlth, Biol Breathing Theme, Winnipeg, MB R3E 3P4, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2015年 / 93卷 / 02期

基金：

加拿大健康研究院;

关键词：

microRNA; lung development; lung diseases; epigenetic regulation; diagnostic tools; therapeutic strategies; CELL-PROLIFERATION; LET-7; MICRORNA; PULMONARY-HYPERTENSION; IN-VIVO; EPIGENETIC REGULATION; HISTONE DEACETYLASES; CHRONIC HYPOXIA; EMBRYONIC LUNG; NUCLEAR EXPORT; RAPID CHANGES;

D O I：

10.1139/bcb-2014-0103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are short endogenous noncoding RNA molecules (similar to 22 nucleotides) that can regulate gene expression at the post-transcription level. Research interest in the role of miRNAs in lung biology is emerging. MiRNAs have been implicated in a range of processes such as development, homeostasis, and inflammatory diseases in lung tissues and are capable of inducing differentiation, morphogenesis, and apoptosis. In recent years, several studies have reported that miRNAs are differentially regulated in lung development and lung diseases in response to epigenetic changes, providing new insights for their versatile role in various physiological and pathological processes in the lung. In this review, we discuss the contribution of miRNAs to lung development and diseases and possible future implications in the field of lung biology.

引用

页码：139 / 148

页数：10

共 133 条

[1] The functions of animal microRNAs [J].