Combining an Hsp70 inhibitor with either an N- or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes

被引：13
作者：
Wang, Y. [1 ]
McAlpine, S. R. [1 ]
机构：
[1] Univ New S Wales, Dept Chem, Sydney, NSW 2052, Australia
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 12期
关键词：
SHOCK-PROTEIN; 90; INDUCED APOPTOSIS; SMALL-MOLECULE; CANCER; SANSALVAMIDE; BINDING;
D O I：
10.1039/c5ob00147a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones' cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90's C-terminus, when used in combination with Hsp70 inhibitors, produces a synergistic and highly relevant dual chemotherapy regimen.
引用
收藏
页码：3691 / 3698
页数：8
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