Parallel-stranded hairpins containing 8-aminopurines.: Novel efficient probes for triple-helix formation

被引：13
作者：
Aviñó, A
Morales, JC
Frieden, M
de la Torre, BG
García, RG
Cubero, E
Luque, FJ
Orozco, M
Azorín, F
Eritja, R
机构：
[1] Cygene Spain SL, E-08028 Barcelona, Spain
[2] CSIC, Inst Mol Biol, E-08034 Barcelona, Spain
[3] Univ Barcelona, E-08028 Barcelona, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期
关键词：
D O I：
10.1016/S0960-894X(01)00295-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure, (C) 2001 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1761 / 1763
页数：3
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