Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation

被引：8

作者：

Liang, Rui ^{[1
]}

Yuan, Yaqin ^{[1
]}

Bai, Yakun ^{[2
]}

Liu, Xinnan ^{[1
]}

Chen, Jieqiong ^{[1
]}

Jiang, Dandan

Meng, Dehua ^{[3
]}

Chen, Guangjie ^{[1
]}

Li, Bin ^{[1
,4
,5
,6
,7
]}

Zhou, Luxian

Guo, Wenzhi ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Resp & Crit Care Med,Sch Med, Ctr Immune Related Dis,Shanghai Inst Immunol, Dept Immunol & Microbiol,Ruijin Hosp, Shanghai, Peoples R China

[2] Zhengzhou Univ, Dept Hepatobiliary & Pancreat Surg, Henan Key Lab Digest Organ Transplantat, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Dept Orthopaed, Shanghai, Peoples R China

[4] Tongji Univ, Shanghai Pulm Hosp, Clin Translat Res Ctr, Dept Thorac Surg,Sch Med, Shanghai, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Guanghua Integrat Med Hosp, Inst Arthrit Res, Shanghai, Peoples R China

[6] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Dept Integrated TCM & Western Med, Shanghai 200443, Peoples R China

[7] Shenzhen Key Lab Immun & Inflammatory Dis, Shenzhen 518036, Guangdong, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 110卷

基金：

美国国家科学基金会;

关键词：

Neobavaisoflavone (NBIF); Bone marrow-derived mast cells (BMMCs); Asthma; Passive systemic anaphylaxis (PSA); ASTHMA; THERAPY; IGE;

D O I：

10.1016/j.intimp.2022.108953

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neobavaisoflavone (NBIF), a monomolecular compound extracted from Psoralea corylifolia (Leguminosae), is commonly used in traditional Chinese medicine for multiple purposes. NBIF is known to exert anti-fungal and anti-tumor effects, and promote bone formation. Whether NBIF exhibits anti-allergic effects by regulating mast cell activation remains unclear. Therefore, we designed this study to investigate the anti-allergic effects of NBIF on IgE/Ag-induced mouse bone marrow-derived mast cells and ovalbumin-induced asthma, and the passive systemic anaphylaxis (PSA) reaction in mice. Our results showed that NBIF suppresses the production of leukotriene C4, prostaglandin D2 and inflammatory cytokines, and decreases the degranulation of BMMCs stimulated by IgE/Ag. A thorough investigation ascertained that NBIF suppresses the phosphorylation of mitogen-activated protein kinases, and represses the nuclear factor-.B-related signaling pathway. In addition, the oral administration of NBIF in mice inhibited the IgE-induced PSA reaction in a dose-dependent manner. Overall, we provide new insights into how NBIF regulates the IgE/Ag-mediated signaling pathways. Moreover, our investigation promotes the potential use of NBIF in treating allergy and asthma.

引用

页数：8

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