Effect of single bout downhill running on the serum irisin concentrations in rats

被引：6

作者：

Murao, Masanobu ^{[1
]}

Imano, Tetsuo ^{[1
,2
]}

Akiyama, Junichi ^{[1
]}

Kawakami, Teruhiko ^{[1
]}

Nakajima, Masaaki ^{[1
]}

机构：

[1] Kibi Int Univ, Grad Sch Hlth Sci, 8 Iga Machi, Takahashi, Okayama 7168508, Japan

[2] Fukuyama Med Coll, Dept Phys Therapy, Fukuyama, Hiroshima, Japan

来源：

GROWTH FACTORS | 2019年 / 37卷 / 5-6期

关键词：

downhill running; eccentric contraction; myokine; Irisin; SKELETAL-MUSCLE; EXERCISE; MYOKINE; BONE;

D O I：

10.1080/08977194.2020.1742118

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study aimed to characterize the effect of different running modes on serum irisin concentrations in rats. A total of 18, 10-week-old rats were divided into three groups; control group, 16 degrees uphill running group (concentric exercise; CON) and, -16 degrees downhill running group (eccentric exercise; ECC). The running group's rats ran on the inclined treadmill at 16 m/min, for a total of 90 min. Blood was drawn from the rats, 48 h after running, after which the rats were anesthetized. The serum concentrations of irisin were measured using enzyme-linked immunosorbent assays. Vastus intermedius was collected for immunohistochemical analysis. After multiple comparisons, the ECC showed a significantly high serum irisin concentration (ECC: 28.42 +/- 6.31 ng/ml, CON: 21.27 +/- 3.03 ng/ml) and a larger irisin antibody reactive cross-sectional area in vastus intermedius compared to the CON (p < 0.05). This is the first study to reveal that single bout downhill running increases serum irisin concentrations in rats.

引用

页码：257 / 262

页数：6

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