Adverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study

被引:0
作者
Gonzalez-Martin, G
Caroca, CM
Paris, E
机构
[1] Pontificia Univ Catolica Chile, Fac Chem, Dept Pharm, Div Clin Pharm, Santiago 22, Chile
[2] Pontificia Univ Catolica Chile, Fac Med, Dept Pediat, Santiago 22, Chile
关键词
pediatric patients; adverse drug reactions; drug surveillance;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of this study was to determine the frequency and the characteristics of ADRs in 219 hospitalized pediatric patients, using an intensive and prospective drug surveillance method. The frequency of ADRs in these patients was 13.7%. The systems most commonly affected were the gastrointestinal (32.5%), the central nervous (20.0%), and the metabolic systems (17.5%). Asparaginase, methotrexate, phenytoin, phenobarbital, erythromycin, and salbutamol were probably the drugs associated with the ADRs, According to causality, 54.2% of the ADRs were regarded as probable, and 32.2% as possible. The majority of the ADRs were moderate (51.2%), 27.9% were severe. The main treatment of the ADRs was the withdrawal of the suspected drugs. The length of the slay in the hospital and the total number of drugs given to the patients influenced significantly the frequency of ADRs. 93% of the ADRs were dose-dependent.
引用
收藏
页码:530 / 533
页数:4
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