Viral Factors and Outcomes of Chronic HBV Infection

被引：22

作者：

Huang, Yuehua ^{[1
]}

Lok, Anna S. F. ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2011年 / 106卷 / 01期

关键词：

HEPATITIS-B-VIRUS; HEPATOCELLULAR-CARCINOMA; CORE PROMOTER; RISK; MUTATIONS; ASSOCIATIONS; GENOTYPES;

D O I：

10.1038/ajg.2010.404

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Viral factors associated with outcome of chronic hepatitis B virus (HBV) infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV variants. Mutations in the HBV core promoter region have been shown to be independently associated with hepatocellular carcinoma (HCC). The most common core promoter mutations involve a double substitution A1762T and G1764A (TA). Besides TA mutations, several other core promoter changes have been reported to be associated with the development of cirrhosis and HCC. Future studies should determine if detection of these changes can predict the outcome of patients with chronic HBV infection.

引用

页码：93 / 95

页数：3

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