Sex-dependent association of ACE (I/D) polymorphism with Meniere's disease

被引:1
作者
Mohseni, Mohammad [1 ]
Yazdani, Nasrin [2 ]
Asgarbeik, Saeedeh [2 ]
Daneshi, Ahmad [1 ]
Farhadi, Mohammad [1 ]
Asghari, Alimohamad [1 ]
Mohebbi, Saleh [1 ]
Vahidi, Aida [2 ]
Amoli, Mahsa Mohammad [2 ]
机构
[1] Iran Univ Med Sci, Skull Base Res Ctr, Senses Inst 5, Tehran, Iran
[2] Univ Tehran Med Sci, Amir Alam Hosp, Otorhinolaryngol Res Ctr, Dept Otolaryngol Head & Neck Surg, Tehran, Iran
关键词
Meniere's disease; rs4646994; ACE; Polymorphism; INSERTION/DELETION POLYMORPHISM; GENDER; POPULATION; PREVALENCE; SYSTEM; VIRUS;
D O I
10.1016/j.mgene.2020.100659
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Meniere's disease is an inner ear disorder presenting with recurrent episodic vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness as its main symptoms. Previous studies have demonstrated the role of blood pressure in Meniere's disease. The purpose of this study was to determine the role of ACE, rs4646994 I/D polymorphism in Meniere's disease. Methods and materials: In this case-control study, 67 individuals with Meniere's disease and 100 healthy individuals as a control group were enrolled. Patients DNA samples were extracted from the blood by the phenolchloroform method. The frequency of genotypes were determined by polymerase chain reaction (PCR) technique. Results: The genotypes and allele frequencies were not significantly different between the studied populations (p > .05). There was significant differences for distribution of I/D genotype between females and males (p < .05). The patients with I/D genotype also showed significant difference in the level of hearing (p < .05). Conclusions: This study demonstrates the gender association of ACE rs4646994 polymorphism with Meniere's disease in an Iranian population.
引用
收藏
页数:4
相关论文
共 40 条
  • [1] Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial)
    Adrion, Christine
    Fischer, Carolin Simone
    Wagner, Judith
    Guerkov, Robert
    Mansmann, Ulrich
    Strupp, Michael
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2016, 352
  • [2] Effects of Hypertension on Hearing
    Agarwal, Saurabh
    Mishra, Aseem
    Jagade, Mohan
    Kasbekar, Vimal
    Nagle, Smita K.
    [J]. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, 2013, 65 : S614 - S618
  • [3] Hormones and the auditory system: a review of physiology and pathophysiology
    Al-Mana, D.
    Ceranic, B.
    Djahanbakhch, O.
    Luxon, L. M.
    [J]. NEUROSCIENCE, 2008, 153 (04) : 881 - 900
  • [4] ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension
    Ali, Ahmad
    Alghasham, Abdullah
    Ismail, Hisham
    Dowaidar, Moataz
    Settin, Ahmad
    [J]. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2013, 14 (04) : 348 - 353
  • [5] Bhavani B. A., 2004, International Journal of Human Genetics, V4, P207
  • [6] The genetics of Menieres disease
    Chiarella, Giuseppe
    Petrolo, C.
    Cassandro, E.
    [J]. APPLICATION OF CLINICAL GENETICS, 2015, 8 : 9 - 16
  • [7] Medical Management Of Meniere's Disease
    Coelho, Daniel H.
    Lalwani, Anil K.
    [J]. LARYNGOSCOPE, 2008, 118 (06) : 1099 - 1108
  • [8] Vascular injury in systemic sclerosis: angiotensin-converting enzyme insertion/deletion polymorphism.
    Fatini C.
    Guiducci S.
    Abbate R.
    Matucci-Cerinic M.
    [J]. Current Rheumatology Reports, 2004, 6 (2) : 149 - 155
  • [9] Ferri GG., 2010, AUDIOL MED, V8, P33, DOI [10.3109/16513861003647043, DOI 10.3109/16513861003647043]
  • [10] Tinnitus and arterial hypertension: a systematic review
    Figueiredo, Ricardo Rodrigues
    de Azevedo, Andreia Aparecida
    Penido, Norma de Oliveira
    [J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2015, 272 (11) : 3089 - 3094