Novel N-heterocyclic ylideneamine gold(I) complexes: synthesis, characterisation and screening for antitumour and antimalarial activity

被引：32

作者：

Coetzee, Jacorien ^{[1
]}

Cronje, Stephanie ^{[1
]}

Dobrzanska, Liliana ^{[1
]}

Raubenheimer, Helgard G. ^{[1
]}

Joone, Gisela ^{[2
]}

Nell, Margo J. ^{[2
]}

Hoppe, Heinrich C. ^{[3
]}

机构：

[1] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7602 Stellenbosch, South Africa

[2] Univ Pretoria, Fac Med, Dept Pharmacol, ZA-0001 Pretoria, South Africa

[3] CSIR, Biosci, ZA-0001 Pretoria, South Africa

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

BIGUANIDE DERIVATIVES; CARBENE COMPLEXES; METFORMIN; PENTAFLUOROPHENYL; RECEPTORS; DINUCLEAR; TOXICITY; LIGANDS; SALTS; DRUG;

D O I：

10.1039/c0dt01312a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ylideneamine functionalised heterocyclic ligands, 1,3-dimethyl-1,3-dihydro-benzimidazol-2-ylideneamine (I), 3-methyl-3H-benzothiazol-2-ylideneamine (II) or 3,4-dimethyl-3H-thiazol-2-ylideneamine (III), were employed in the preparation of a series of both charged and neutral gold(I) complexes consisting either of a Au(C6F5) fragment (1-3), a [Au(PPh3)](+) unit (4-6) or a [Au(NHC)](+) unit (7) coordinated to the imine nitrogen of the neutral ylideneamine ligand. These complexes were fully characterised by various techniques including X-ray diffraction. In addition, the antitumour and antimalarial potential of selected compounds were assessed in a preliminary study aimed at determining the medicinal value of such compounds. Complexation of the azol-2-ylideneamine ligands with [Au(PPh3)](+) increases their antitumour as well as antimalarial activity.

引用

页码：1471 / 1483

页数：13

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