Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy

被引：15

作者：

Hara, Takuto ^{[1
]}

Terakawa, Tomoaki ^{[1
]}

Hyodo, Toshiki ^{[2
]}

Jinbo, Naoe ^{[2
]}

Nakano, Yuzo ^{[1
]}

Fujisawa, Masato ^{[1
]}

机构：

[1] Kobe Univ, Div Urol, Grad Sch Med, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Div Diagnost Pathol, Grad Sch Med, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

来源：

UROLOGY CASE REPORTS | 2021年 / 39卷

关键词：

Presurgical therapy; Nephrectomy; Renal cell carcinoma; TKI/IO combination Therapy;

D O I：

10.1016/j.eucr.2021.101800

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she un-derwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/ Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4.

引用

页数：3

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