Genome-wide analysis reveals the differential regulations of mRNAs and miRNAs in Dorset and Small Tail Han sheep muscles

被引：50
|
作者：
Miao, Xiangyang [1 ]
Luo, Qingmiao [1 ]
Qin, Xiaoyu [1 ]
机构：
[1] Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China
来源：
GENE | 2015年 / 562卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Sheep; Gene expression regulation; mRNA; miRNA; UNFOLDED PROTEIN RESPONSE; HEAT-SHOCK PROTEINS; SKELETAL-MUSCLE; GENE-EXPRESSION; MEAT QUALITY; TRANSCRIPTOME ANALYSIS; LONGISSIMUS-DORSI; GROWTH-HORMONE; PATHWAY; MICRORNAS;
D O I：
10.1016/j.gene.2015.02.070
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Sheep are highly diverse species raised for meat and other agricultural products. The aim of the present study was to investigate the genetic regulators that could control muscle growth and development in different sheep breeds. The study showed that the differentially expressed genes are involved in various cellular activities, such as metabolic cascades, catalytic function and signaling pathway. Many signaling molecules are also found to be differentially expressed, suggesting important roles of signaling pathways contributing to genetic diversity and sheep development. Analysis of miRNAs suggested important roles of miRNAs in controlling muscle differences. This study provided a genome-wide resolution of mRNA and miRNA regulations in muscles from Dorset and Han sheep. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：188 / 196
页数：9
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