Effect of Early Diabetes on the Response to Norepinephrine and Dopamine in Pithed Wistar Kyoto and Spontaneously Hypertensive Rats

被引：6

作者：

Hong, Enrique ^{[2
]}

Huang, Fengyang ^{[3
]}

Villafana, Santiago ^{[1
]}

机构：

[1] Escuela Super Med, Inst Politecn Nacl, Secc Posgrad, Mexico City 11340, DF, Mexico

[2] Inst Politecn Nacl, Dept Farmacobiol, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico

[3] Hosp Infantil Mexico Dr Federico Gomez, Dept Farmacol & Toxicol, Mexico City, DF, Mexico

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2010年 / 32卷 / 06期

关键词：

norepinephrine; dopamine; diabetes; hypertension; vasopressor; ENDOTHELIUM-DEPENDENT RELAXATION; NITRIC-OXIDE; VASCULAR RESPONSIVENESS; RESISTANCE ARTERIES; AORTA; INHIBITION; MODULATION; PATHWAY; DISEASE; MUSCLE;

D O I：

10.3109/10641961003628544

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes has been related to changes in vascular responses, mainly an increase in the vasoconstrictor responses and a decrease in the vasodilator responses. The literature has now begun to study the effects of diabetes in the early stages of development; the first studies on these stages indicate that diabetes produces different changes compared to the advanced stages. For that reason, the aim of this work was to evaluate the responses to norepinephrine and dopamine on normotensive and hypertensive rats with 4 weeks of diabetes evolution. The results showed that 4 weeks of diabetes produces a decrease of the vasopressor response to both agents (norepinephrine and dopamine). These results suggest that in the early stages, there are changes that help to decrease the pressor responses and these changes could disappear in the advanced stages.

引用

页码：390 / 394

页数：5

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