The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery

被引：85

作者：

Brown, Charles H. ^{[1
]}

Max, Laura ^{[1
]}

LaFlam, Andrew ^{[1
]}

Kirk, Lou ^{[1
]}

Gross, Alden ^{[2
]}

Arora, Rakesh ^{[3
]}

Neufeld, Karin ^{[4
]}

Hogue, Charles W. ^{[1
]}

Walston, Jeremy ^{[5
]}

Pustavoitau, Aliaksei ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Univ Manitoba, St Boniface Hosp, Dept Surg, Winnipeg, MB, Canada

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, Baltimore, MD USA

来源：

ANESTHESIA AND ANALGESIA | 2016年 / 123卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CONFUSION ASSESSMENT METHOD; OLDER-ADULTS; NEUROINFLAMMATION; INFLAMMATION; VALIDATION; PREDICTOR; PHENOTYPE; MORTALITY; FRACTURE; OUTCOMES;

D O I：

10.1213/ANE.0000000000001271

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Delirium is common after cardiac surgery, and preoperative identification of high-risk patients could guide prevention strategies. We prospectively measured frailty in 55 patients before cardiac surgery and assessed postoperative delirium using a validated chart review. The prevalence of frailty was 30.9%. Frail patients had a higher incidence of delirium (47.1%) compared with nonfrail patients (2.6%; P < 0.001). In multivariable models, the relative risk of delirium was >= 2.1-fold greater in frail compared with nonfrail patients (relative risk, 18.3; 95% confidence interval, 2.1-161.8; P = 0.009). Frailty may identify patients who would benefit from delirium-prevention strategies because of increased baseline risk for delirium.

引用

页码：430 / 435

页数：6

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