Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

被引：25
作者：
Lettieri, Stefania [1 ]
d'Amora, Marta [2 ]
Camisasca, Adalberto [1 ,3 ]
Diaspro, Alberto [2 ,4 ,5 ]
Giordani, Silvia [1 ,6 ]
机构：
[1] IIT, Nano Carbon Mat, Via Livorno 60, I-10144 Turin, Italy
[2] IIT, Nanoscopy, Via Morego 30, I-16163 Genoa, Italy
[3] Univ Genoa, Dept Chem, Via Dodecaneso 31, I-16145 Genoa, Italy
[4] IIT, NIC IIT, Via Morego 30, I-16163 Genoa, Italy
[5] Univ Genoa, Dept Phys, Via Dodecaneso 33, I-16145 Genoa, Italy
[6] Univ Turin, Dept Chem, Via Giuria 7, I-10125 Turin, Italy
来源：
BEILSTEIN JOURNAL OF NANOTECHNOLOGY | 2017年 / 8卷
关键词：
carbon nanomaterials; fluorescence; imaging; nanomedicine; nano-onion; PH; FUNCTIONALIZATION; PROBES; TUMORS;
D O I：
10.3762/bjnano.8.188
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a pi-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylamino functionalities attached to the BODIPY core. The on/off emission of the fluorescent CNOs is fast and reversible both in solution and in vitro, making this nanomaterial suitable as pH-dependent probes for diagnostic applications.
引用
收藏
页码：1878 / 1888
页数：11
相关论文
共 50 条
[31]   Solubilization of carbon nanoparticles, nanotubes, nano-onions, and nanodiamonds through covalent functionalization with sucrose [J].
O. V. Kuznetsov ;
M. X. Pulikkathara ;
R. F. M. Lobo ;
V. N. Khabasheskua .
Russian Chemical Bulletin, 2010, 59 :1495-1505
[32]   On the morphological, structural and electrochemical properties of entangled Cu-filled carbon nano-onions [J].
Zhang, X. ;
Medranda, D. ;
Borowiec, J. ;
Yan, K. ;
Zhang, J. ;
Wang, S. ;
Boi, F. S. .
RSC ADVANCES, 2018, 8 (13) :6870-6877
[33]   Facile chemical vapor deposition (CVD) method for synthesis of high purity carbon nano-onions [J].
Merlano, Aura S. ;
Palacio, Lina Marcela Hoyos ;
Cacua, Karen ;
Rudas, Juan Sebastian ;
Munera, Sebastian Meneses ;
Vazquez-Fletes, Roberto Carlos ;
Cornelio, Jesus Antonio Carlos .
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES, 2025, 33 (02) :171-177
[34]   Water soluble carbon nano-onions from wood wool as growth promoters for gram plants [J].
Sonkar, Sumit Kumar ;
Roy, Manas ;
Babar, Dipak Gorakh ;
Sarkar, Sabyasachi .
NANOSCALE, 2012, 4 (24) :7670-7675
[35]   Preparation of carbon nano-onions by the low-temperature unfolding of MWCNTs via interaction with theraphthal [J].
Kharissova, Oxana V. ;
Dias, H. V. Rasika ;
Kharisov, Boris I. ;
Jiang, Jiechao .
RSC ADVANCES, 2015, 5 (71) :57764-57770
[36]   Electrochemical Properties of Oxidized Carbon Nano-Onions: DRIFTS-FTIR and Raman Spectroscopic Analyses [J].
Plonska-Brzezinska, Marta E. ;
Dubis, Alina T. ;
Lapinski, Andrzej ;
Villalta-Cerdas, Adrian ;
Echegoyen, Luis .
CHEMPHYSCHEM, 2011, 12 (14) :2659-2668
[37]   Facile Functionalization of Multilayer Fullerenes (Carbon Nano-Onions) by Nitrene Chemistry and "Grafting from" Strategy [J].
Zhou, Li ;
Gao, Chao ;
Zhu, Dandan ;
Xu, Weijian ;
Chen, Fanqing Frank ;
Palkar, Amit ;
Echegoyen, Luis ;
Kong, Eric Siu-Wai .
CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (06) :1389-1396
[38]   Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions [J].
Viviana Maffeis ;
Lisa Moni ;
Daniele Di Stefano ;
Silvia Giordani ;
Renata Riva .
Frontiers of Chemical Science and Engineering, 2020, 14 :76-89
[39]   Synthesis and Characterization of Far-Red/NIR-Fluorescent BODIPY Dyes, Solid-State Fluorescence, and Application as Fluorescent Tags Attached to Carbon Nano-onions [J].
Bartelmess, Juergen ;
Baldrighi, Michele ;
Nardone, Valentina ;
Parisini, Emilio ;
Buck, David ;
Echegoyen, Luis ;
Giordani, Silvia .
CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (27) :9727-9732
[40]   Supramolecular Functionalisation of B/N Co-Doped Carbon Nano-Onions for Novel Nanocarrier Systems [J].
Mohan, Hugh ;
Bincoletto, Valeria ;
Arpicco, Silvia ;
Giordani, Silvia .
MATERIALS, 2022, 15 (17)
12345