Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

被引：25
作者：
Lettieri, Stefania [1 ]
d'Amora, Marta [2 ]
Camisasca, Adalberto [1 ,3 ]
Diaspro, Alberto [2 ,4 ,5 ]
Giordani, Silvia [1 ,6 ]
机构：
[1] IIT, Nano Carbon Mat, Via Livorno 60, I-10144 Turin, Italy
[2] IIT, Nanoscopy, Via Morego 30, I-16163 Genoa, Italy
[3] Univ Genoa, Dept Chem, Via Dodecaneso 31, I-16145 Genoa, Italy
[4] IIT, NIC IIT, Via Morego 30, I-16163 Genoa, Italy
[5] Univ Genoa, Dept Phys, Via Dodecaneso 33, I-16145 Genoa, Italy
[6] Univ Turin, Dept Chem, Via Giuria 7, I-10125 Turin, Italy
来源：
BEILSTEIN JOURNAL OF NANOTECHNOLOGY | 2017年 / 8卷
关键词：
carbon nanomaterials; fluorescence; imaging; nanomedicine; nano-onion; PH; FUNCTIONALIZATION; PROBES; TUMORS;
D O I：
10.3762/bjnano.8.188
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a pi-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylamino functionalities attached to the BODIPY core. The on/off emission of the fluorescent CNOs is fast and reversible both in solution and in vitro, making this nanomaterial suitable as pH-dependent probes for diagnostic applications.
引用
收藏
页码：1878 / 1888
页数：11
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