Identification of Hematological change and Seroprevelance of Helicobacter Pylori infection in patients with perforated Peptic ulcer in district Peshawar KPK, Pakistan

Helicobacter pylori (H. pylori) Infection is a major gastrointestinal tract pathogen that has been involved in a wide range of gastrointestinal infection, with gastritis, dyspepsia, peptic ulcer, gastrointestinal carcinoma, and lymphoma of the lymphoma associated with mucosa. The frequency of H. pylori infection in developing countries, H. pylori infection is more than in developed countries, while Pakistan has inadequate data on its frequency. The Purpose of this study to determine the prevalence of Helicobacter pylori infection in patients with perforated peptic ulcer, this prospective study was conducted in the Department of Surgery at Lady Reading Hospital Peshawar Kp Pakistan, All patients were evaluated by full history, clinical examination and relevant laboratory investigations including. X-ray chest and abdomen, ultrasound abdomen, serum anti H-Pylori, biopsy and histopathology for detection of helicobacter pylori infection and perforation. The data was collected through pre-designed proforma and analyzed by SPSS version 10.00. A total 96 patients were diagnosed as case of perforated peptic ulcer out of total of which 75 were males and 21 were females and majority of patients were more than 30 years of age with mean age of 44.6 years. The serological test for helicobacter pylori was positive in all 96 cases; however histopathology of biopsy yields H. pylori in 73 (76.06%) cases. On exploratory laparotomy perforated duodenal ulcer was found in 75(78.12%) patients while 26(27.08%) patients had perforated gastric ulcer. The biopsy proven prevalence of perforated peptic ulcer, one of the life threatening complications of H. Pylori, was is 78% in this study.