First synthesis of nitrosporeusines, alkaloids with multiple biological activities

被引：12
作者：
Philkhana, Satish Chandra [1 ]
Jachak, Gorakhnath R. [1 ]
Gunjal, Vidya B. [1 ]
Dhage, Nagsen M. [1 ]
Bansode, Ajay H. [1 ]
Reddy, D. Srinivasa [1 ]
机构：
[1] CSIR, Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 10期
关键词：
Influenza H1N1 virus; Michael reaction; Enzymatic resolution; Nitrosporeusine; Maleimycin; CONJUGATE ADDITION; THIOACETIC ACID; INFLUENZA-VIRUSES; FORMAL SYNTHESIS; RESISTANCE; SUSCEPTIBILITY; UPDATE;
D O I：
10.1016/j.tetlet.2015.01.143
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product, maleimycin, in optically pure form using a gram-scale enzymatic resolution method. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1252 / 1254
页数：3
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