The rotenone model of Parkinson's disease: genes, environment and mitochondria

被引：173
作者：
Greenamyre, JT [1 ]
Betarbet, R [1 ]
Sherer, TB [1 ]
机构：
[1] Emory Univ, Ctr Neurodegenerat Dis, Atlanta, GA 30322 USA
来源：
PARKINSONISM & RELATED DISORDERS | 2003年 / 9卷
关键词：
Parkinson's disease; Lewy bodies; pathogenesis;
D O I：
10.1016/S1353-8020(03)00023-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is occasionally caused by single gene mutations or by single toxic exposures, but most cases of PD are probably caused by some combination of genetic susceptibility and environmental exposure. Using rotenone as a prototype for an environmental toxicant, we argue here that genetic and environmental causes of PD converge on common pathogenic mechanisms. If so, protective strategies devised for one type of PD may be broadly useful for other forms of the disease. (C) 2003 Published by Elsevier Ltd.
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收藏
页码：S59 / S64
页数：6
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