Finding and using hyperthermophilic enzymes

被引：143

作者：

Adams, MWW ^{[1
]}

Kelly, RM

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] N Carolina State Univ, Dept Chem Engn, Raleigh, NC 27695 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-7799(98)01193-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent developments have enhanced the prospects for the discovery of hyperthermophilic enzymes. This is important because the intrinsic basis underlying the extraordinary thermostability of hyperthermophilic enzymes has yet to be revealed, and so engineering this characteristic into less thermophilic enzymes is not possible at this time. Successful efforts to clone and express the genes encoding hyperthermophilic enzymes in mesophilic hosts have improved the availability of high-temperature biocatalysts. The remaining task is the identification of opportunities to make strategic use of the thermoactivity and thermostability of hyperthermophilic enzymes.

引用

页码：329 / 332

页数：4

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