Post-translational modifications in T cells in systemic erythematosus lupus

被引:7
作者
Yang, Fan [1 ]
Lin, Jin [2 ]
Chen, Weiqian [2 ]
机构
[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis,Sch Med, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 1, Div Rheumatol, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
systemic erythematosus lupus; post-translational modifications; T cells; signaling pathway; RECEPTOR ZETA-CHAIN; LINEAGE LYMPHOMA-B; ROR-GAMMA-T; IMMUNE-RESPONSES; GENE-EXPRESSION; ERM PROTEINS; TYROSINE PHOSPHORYLATION; ARGININE METHYLATION; DEFECTIVE EXPRESSION; NEGATIVE REGULATION;
D O I
10.1093/rheumatology/keab095
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Systemic erythematosus lupus (SLE) is a classic autoimmune disease characterized by multiple autoantibodies and immune-mediated tissue damage. The aetiology of this disease is still unclear. A new drug, belimumab, which acts against the B-lymphocyte stimulator (BLyS), can effectively improve the condition of SLE patients, but it cannot resolve all SLE symptoms. The discovery of novel, precise therapeutic targets is urgently needed. It is well known that abnormal T-cell function is one of the most crucial factors contributing to the pathogenesis of SLE. Protein post-translational modifications (PTMs), including phosphorylation, glycosylation, acetylation, methylation, ubiquitination and SUMOylation have been emphasized for their roles in activating protein activity, maintaining structural stability, regulating protein-protein interactions and mediating signalling pathways, in addition to other biological functions. Summarizing the latest data in this area, this review focuses on the potential roles of diverse PTMs in regulating T-cell function and signalling pathways in SLE pathogenesis, with the goal of identifying new targets for SLE therapy.
引用
收藏
页码:2502 / 2516
页数:15
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