Post-translational modifications in T cells in systemic erythematosus lupus

被引：7

作者：

Yang, Fan ^{[1
]}

Lin, Jin ^{[2
]}

Chen, Weiqian ^{[2
]}

机构：

[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis,Sch Med, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Div Rheumatol, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

RHEUMATOLOGY | 2021年 / 60卷 / 06期

基金：

中国国家自然科学基金;

关键词：

systemic erythematosus lupus; post-translational modifications; T cells; signaling pathway; RECEPTOR ZETA-CHAIN; LINEAGE LYMPHOMA-B; ROR-GAMMA-T; IMMUNE-RESPONSES; GENE-EXPRESSION; ERM PROTEINS; TYROSINE PHOSPHORYLATION; ARGININE METHYLATION; DEFECTIVE EXPRESSION; NEGATIVE REGULATION;

D O I：

10.1093/rheumatology/keab095

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic erythematosus lupus (SLE) is a classic autoimmune disease characterized by multiple autoantibodies and immune-mediated tissue damage. The aetiology of this disease is still unclear. A new drug, belimumab, which acts against the B-lymphocyte stimulator (BLyS), can effectively improve the condition of SLE patients, but it cannot resolve all SLE symptoms. The discovery of novel, precise therapeutic targets is urgently needed. It is well known that abnormal T-cell function is one of the most crucial factors contributing to the pathogenesis of SLE. Protein post-translational modifications (PTMs), including phosphorylation, glycosylation, acetylation, methylation, ubiquitination and SUMOylation have been emphasized for their roles in activating protein activity, maintaining structural stability, regulating protein-protein interactions and mediating signalling pathways, in addition to other biological functions. Summarizing the latest data in this area, this review focuses on the potential roles of diverse PTMs in regulating T-cell function and signalling pathways in SLE pathogenesis, with the goal of identifying new targets for SLE therapy.

引用

收藏

页码：2502 / 2516

页数：15

相关论文

共 149 条

[1] Linker for activation of T cells is displaced from lipid rafts and decreases in lupus T cells after activation via the TCR/CD3 pathway [J].

Abdoel, Nursamaa ;

Brun, Susana ;

Bracho, Carmen ;

Rodriguez, Martin A. ;

Blasini, Ana M. .

CLINICAL IMMUNOLOGY, 2012, 142 (03) :243-251

[2] Down regulation of the TCR complex CD3ζ-chain on CD3+T cells: a potential mechanism for helminth-mediated immune modulation [J].

Appleby, Laura J. ;

Nausch, Norman ;

Heard, Francesca ;

Erskine, Louise ;

Bourke, Claire D. ;

Midzi, Nicholas ;

Mduluza, Takafira ;

Allen, Judith E. ;

Mutapi, Francisca .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[3] Protein kinase Cε mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2) [J].

Aziz, M. H. ;

Hafeez, B. B. ;

Sand, J. M. ;

Pierce, D. B. ;

Aziz, S. W. ;

Dreckschmidt, N. E. ;

Verma, A. K. .

ONCOGENE, 2010, 29 (21) :3100-3109

[4] Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [J].

Bachmaier, K ;

Krawczyk, C ;

Kozieradzki, I ;

Kong, YY ;

Sasaki, T ;

Oliveira-dos-Santos, A ;

Mariathasan, S ;

Bouchard, D ;

Wakeham, A ;

Itie, A ;

Le, J ;

Ohashi, PS ;

Sarosi, I ;

Nishina, H ;

Lipkowitz, S ;

Penninger, JM .

NATURE, 2000, 403 (6766) :211-216

[5] Endocytic events in TCR signaling: focus on adapters in microclusters [J].

Balagopalan, Lakshmi ;

Barr, Valarie A. ;

Samelson, Lawrence E. .

IMMUNOLOGICAL REVIEWS, 2009, 232 :84-98

[6] PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21 [J].

Bocharnikov, Alexandra, V ;

Keegan, Joshua ;

Wacleche, Vanessa S. ;

Cao, Ye ;

Fonseka, Chamith Y. ;

Wang, Guoxing ;

Muise, Eric S. ;

Zhang, Kelvin X. ;

Arazi, Arnon ;

Keras, Gregory ;

Li, Zhihan J. ;

Qu, Yujie ;

Gurish, Michael F. ;

Petri, Michelle ;

Guyon, Jill P. ;

Putterman, Chaim ;

Wofsy, David ;

James, Judith A. ;

Guthridge, Joel M. ;

Diamond, Betty ;

Anolik, Jennifer H. ;

Mackey, Matthew F. ;

Alves, Stephen E. ;

Nigrovic, Peter A. ;

Costenbader, Karen H. ;

Brenner, Michael B. ;

Lederer, James A. ;

Rao, Deepak A. .

JCI INSIGHT, 2019, 4 (20)

[7] Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo [J].

Bosisio, Daniela ;

Vulcano, Marisa ;

Del Prete, Annalisa ;

Sironi, Marina ;

Salvi, Valentina ;

Salogni, Laura ;

Riboldi, Elena ;

Leoni, Flavio ;

Dinarello, Charles A. ;

Girolomoni, Giampiero ;

Sozzani, Silvano .

JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (06) :1540-1548

[8] The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies [J].

Brahms, H ;

Raymackers, J ;

Union, A ;

de Keyser, F ;

Meheus, L ;

Lührmann, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :17122-17129

[9] Evidences for ubiquitination and intracellular trafficking of LAT, the linker of activated T cells [J].

Brignatz, C ;

Restouin, A ;

Bonello, G ;

Olive, D ;

Collette, Y .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2005, 1746 (02) :108-115

[10] Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4+ and CD8+ T-cell dysfunction in patients with active SLE [J].

Cai Gang ;

Yang Jiahui ;

Wang Huaizhou ;

Cai Qing ;

Zhao Dongbao ;

Shen Qian .

CELLULAR IMMUNOLOGY, 2009, 258 (01) :83-89

← 1 2 3 4 5 6 7 8 9 10 →