In vitro interaction profiles of the new antitubercular drugs bedaquiline and delamanid with moxifloxacin against clinical Mycobacterium tuberculosis isolates
被引:10
作者:
Chandramohan, Yuvaraj
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Natl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Chandramohan, Yuvaraj
[1
]
Padmanaban, Venkatesan
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Natl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Padmanaban, Venkatesan
[1
]
Bethunaickan, Ramalingam
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机构:
Natl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
ICMR Natl Inst Nutr, Pathol & Microbiol Div, Hyderabad, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Bethunaickan, Ramalingam
[1
,4
]
Tripathy, Srikanth
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Natl Inst Res TB, Chennai 600031, Tamil Nadu, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Tripathy, Srikanth
[2
]
Swaminathan, Soumya
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机构:
Indian Council Med Res, New Delhi 110029, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Swaminathan, Soumya
[3
]
Ranganathan, Uma Devi
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Natl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, IndiaNatl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
Ranganathan, Uma Devi
[1
]
机构:
[1] Natl Inst Res TB, Dept Immunol, 1 Mayor Sathyamoorthy Rd, Chennai 600031, Tamil Nadu, India
[2] Natl Inst Res TB, Chennai 600031, Tamil Nadu, India
[3] Indian Council Med Res, New Delhi 110029, India
Objectives: The emergence of drug-resistant tuberculosis (TB) poses a serious challenge to existing anti-TB therapies. Hence, there is a direct need for identification of new drugs and effective combination regimens. Methods: In this study, minimum inhibitory concentrations (MICs) of the anti-TB drugs bedaquiline (BDQ), delamanid (DEL) and moxifloxacin (MFX) were evaluated using a resazurin microtiter assay (REMA) against five drug-resistant clinicalMycobacterium tuberculosis (MTB) isolates as well as the drug-susceptible reference strain H37Rv. In addition, their fractional inhibitory concentration indices (FICIs) were evaluated using a REMA-based calorimetric chequerboard assay to assess their interaction profiles against the MTB isolates. Results: The FICI indicated that BDQ acted synergistically with DEL against isoniazid (INH)-monoresistant, rifampicin (RIF)-monoresistant and extensively drug-resistant (XDR) clinical MTB isolates. In addition, the combination of DEL acted synergistically with MFX against INH-monoresistant, RIF-monoresistant and XDR clinical MTB isolates. Moreover, the combination of BDQ and MFX showed a synergistic effect against RIF-monoresistant and pre-XDR clinical MTB isolates. DEL at 0.125 x MIC (i.e. 0.015 mu g/mL) used in combination with BDQ at 0.25 x MIC (i.e. 0.015 mu g/mL) had a stronger bactericidal effect against the XDR-TB clinical isolate than DEL alone at 1 x MIC (i.e. 0.125 mu g/mL). Conclusion: Synergistic and additive effects between these two-drug combinations offer an attractive chemotherapeutic regimen against drug-resistant clinical MTB isolates. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Tahlan, Kapil
;
Wilson, Regina
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机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Infect Dis, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Ruy V Lourenco Ctr Study Emerging & Reemerging Pa, Newark, NJ 07103 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Wilson, Regina
;
Kastrinsky, David B.
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机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Kastrinsky, David B.
;
Arora, Kriti
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机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Arora, Kriti
;
Nair, Vinod
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机构:
NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Nair, Vinod
;
Fischer, Elizabeth
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机构:
NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Fischer, Elizabeth
;
Barnes, S. Whitney
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机构:
Novartis Res Fdn, Genom Inst, San Diego, CA USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Barnes, S. Whitney
;
Walker, John R.
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机构:
Novartis Res Fdn, Genom Inst, San Diego, CA USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Walker, John R.
;
Alland, David
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机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Infect Dis, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Ruy V Lourenco Ctr Study Emerging & Reemerging Pa, Newark, NJ 07103 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Alland, David
;
Barry, Clifton E., III
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机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Barry, Clifton E., III
;
Boshoff, Helena I.
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Tahlan, Kapil
;
Wilson, Regina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Infect Dis, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Ruy V Lourenco Ctr Study Emerging & Reemerging Pa, Newark, NJ 07103 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Wilson, Regina
;
Kastrinsky, David B.
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Kastrinsky, David B.
;
Arora, Kriti
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Arora, Kriti
;
Nair, Vinod
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Nair, Vinod
;
Fischer, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, Res Technol Branch, Rocky Mt Labs, NIH, Hamilton, MT 59840 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Fischer, Elizabeth
;
Barnes, S. Whitney
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Barnes, S. Whitney
;
Walker, John R.
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Walker, John R.
;
Alland, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Infect Dis, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Ruy V Lourenco Ctr Study Emerging & Reemerging Pa, Newark, NJ 07103 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Alland, David
;
Barry, Clifton E., III
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
Barry, Clifton E., III
;
Boshoff, Helena I.
论文数: 0引用数: 0
h-index: 0
机构:
NIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USANIAID, TB Res Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA