Design of artificial metallonucleases with oxidative mechanism

被引：226
作者：
Jiang, Qin
Xiao, Nan
Shi, Pengfei
Zhu, Yangguang
Guo, Zijian [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[2] Huaihai Inst Technol, Dept Chem, Lianyungang 222005, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2007年 / 251卷 / 15-16期
基金：
中国国家自然科学基金;
关键词：
artificial metallonucleases; design strategy; DNA; oxidative cleavage; selectivity;
D O I：
10.1016/j.ccr.2007.02.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The rational design of artificial metallonucleases capable of cleaving DNA in a controllable manner is highly desired due to their potential application in biology and medicine. This review will highlight the most recent progress in the area of artificial metallonucleases employing an oxidative mechanism, focusing on the development of methodologies for cleavage detection, understanding of the factors governing the cleavage efficacy and selectivity, and design strategies for the achievement of high cleavage efficacy. The challenging problems in mimicking the reactivity of natural nucleases will also be discussed. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：1951 / 1972
页数：22
相关论文
共 154 条
[61]   Long-range radical cation migration in DNA: Investigation of the mechanism [J].
Joy, A ;
Schuster, GB .
CHEMICAL COMMUNICATIONS, 2005, (22) :2778-2784
[62]   Acid-base, coordination and oxidative properties of systems containing ATP, L-histidine and Ni(II) ions [J].
Kaczmarek, P ;
Szczepanik, W ;
Jezowska-Bojczuk, M .
DALTON TRANSACTIONS, 2005, (22) :3653-3657
[63]  
KANE SA, 1995, J AM CHEM SOC, V117, P9107, DOI 10.1021/ja00141a001
[64]   The role of chromatin damage in nickel-induced carcinogenesis. A review of recent developments [J].
Kasprzak, KS ;
Bal, W ;
Karaczyn, AA .
JOURNAL OF ENVIRONMENTAL MONITORING, 2003, 5 (02) :183-187
[65]   Spectroscopic studies of the interaction of ferrous bleomycin with DNA [J].
Kemsley, JN ;
Zaleski, KL ;
Chow, MS ;
Decker, A ;
Shishova, EY ;
Wasinger, EC ;
Hedman, B ;
Hodgson, KO ;
Solomon, EI .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (36) :10810-10821
[66]   G-quadruplex DNA as a target for drug design [J].
Kerwin, SM .
CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (04) :441-471
[67]   Simulations of DNA coiling around a synthetic supramolecular cylinder that binds in the DNA major groove [J].
Khalid, S ;
Hannon, MJ ;
Rodger, A ;
Rodger, PM .
CHEMISTRY-A EUROPEAN JOURNAL, 2006, 12 (13) :3493-3506
[68]   SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER [J].
KIM, NW ;
PIATYSZEK, MA ;
PROWSE, KR ;
HARLEY, CB ;
WEST, MD ;
HO, PLC ;
COVIELLO, GM ;
WRIGHT, WE ;
WEINRICH, SL ;
SHAY, JW .
SCIENCE, 1994, 266 (5193) :2011-2015
[69]   Recognition of DNA base pair mismatches by a cyclometalated Rh(III) intercalator [J].
Kisko, JL ;
Barton, JK .
INORGANIC CHEMISTRY, 2000, 39 (21) :4942-4949
[70]   Sequence-selective DNA cleavage by a chimeric metallopeptide [J].
Kovacic, RT ;
Welch, JT ;
Franklin, SJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (22) :6656-6662
234567891011