Design of artificial metallonucleases with oxidative mechanism

被引：225
|
作者：
Jiang, Qin
Xiao, Nan
Shi, Pengfei
Zhu, Yangguang
Guo, Zijian [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[2] Huaihai Inst Technol, Dept Chem, Lianyungang 222005, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2007年 / 251卷 / 15-16期
基金：
中国国家自然科学基金;
关键词：
artificial metallonucleases; design strategy; DNA; oxidative cleavage; selectivity;
D O I：
10.1016/j.ccr.2007.02.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The rational design of artificial metallonucleases capable of cleaving DNA in a controllable manner is highly desired due to their potential application in biology and medicine. This review will highlight the most recent progress in the area of artificial metallonucleases employing an oxidative mechanism, focusing on the development of methodologies for cleavage detection, understanding of the factors governing the cleavage efficacy and selectivity, and design strategies for the achievement of high cleavage efficacy. The challenging problems in mimicking the reactivity of natural nucleases will also be discussed. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：1951 / 1972
页数：22
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