Interleukin-6 implication in prostate cancer

被引:7
作者
Cabrespine, Aurelie
Bay, Jacques-Olivier
Verrelle, Pierre
Morel, Laurent
机构
[1] Hop Hotel Dieu, Serv Therapei Cellulaire & Hematol Clin Adultes, F-63058 Clermont Ferrand, France
[2] Ctr Jean Perrin, F-63011 Clermont Ferrand 1, France
[3] Univ Clermont Ferrand 2, CNRS, UMR 6547, F-63177 Clermont Ferrand, France
关键词
prostate cancer; interleukin-6; hormone-resistance; neuroendocrine; differentiation; apoptosis; angiogenesis;
D O I
10.1684/bdc.2007.0245
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Interleukin-6 (IL-6) is secreted in great quantity in prostatic tumoral glandular tissue with a significant higher rate in hormono-refractory Phase. Importance of IL-6 dependent mechanism in prostate cancer progression is well argued. IL-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways : MAPK, STAT3 and PI3K-Akt. As AR is a key factor of prostate cancer progression, IL-6 implication in this activation underlines IL-6 importance in prostate cancer. IL-6 also induces neuroendocrine differentiation, This phenomenon received a detailed attention because it would take part in pathogenicity and progression of prostate cancer. Although complementary studies seem necessary, taking into account its strong implication in prostate cancer progression, IL-6 seems to be a new potential therapeutic target of prostate cancer.
引用
收藏
页码:F29 / F34
页数:6
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