Copper-Catalyzed Aza-Michael Addition of Aromatic Amines or Aromatic Aza-Heterocycles to α,β-Unsaturated Olefins

被引：74

作者：

Kim, Seongcheol ^{[1
]}

Kang, Seongil ^{[1
]}

Kim, Gihyeon ^{[1
]}

Lee, Yunmi ^{[1
]}

机构：

[1] Kwangwoon Univ, Dept Chem, Seoul 01897, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

ASYMMETRIC CONJUGATE ADDITION; BASIC IONIC LIQUID; SOLVENT-FREE; N-HETEROCYCLES; H BONDS; EFFICIENT; ALKENES; ACID; ORGANOCATALYST; HYDROAMINATION;

D O I：

10.1021/acs.joc.6b00341

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and mild Cu-catalyzed conjugate addition reaction of aromatic amines and aromatic aza-heterocycles to alpha,beta-unsaturated olefins is described. The transformation is promoted by 3-7 mol % of a Cu complex generated in situ from a mixture of inexpensive CuCl, a readily available phosphine or imidazolium salt, and KOt-Bu at ambient temperature. A wide range of beta-amino sulfone, beta-amino nitrile, and beta-amino carbonyl compounds is efficiently and selectively synthesized in high yields (62-99%).

引用

页码：4048 / 4057

页数：10

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