ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

被引：86

作者：

Quin, Jaclyn ^{[1
]}

Sedmik, Jiri ^{[1
]}

Vukic, Dragana ^{[1
]}

Khan, Anzer ^{[1
]}

Keegan, Liam P. ^{[1
]}

O'Connell, Mary A. ^{[1
]}

机构：

[1] Masaryk Univ Brno, Cent European Inst Technol, Kamenice 753-5,Pavil A35, CZ-62500 Brno, Czech Republic

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2021年 / 46卷 / 09期

基金：

欧盟地平线“2020”;

关键词：

DYSCHROMATOSIS SYMMETRICA HEREDITARIA; GENETIC POLYMORPHISMS; ANTIVIRAL ACTIVITY; CELLULAR-IMMUNITY; MUTATIONS; RECOGNITION; RNASEH2B; VARIANTS; THERAPY; ASSOCIATIONS;

D O I：

10.1016/j.tibs.2021.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction. These Aicardi-Goutieres syndrome 6 mutations affect adenosine deaminase acting on RNA 1 (ADAR1), which generates inosines in endogenous double-stranded (ds)RNA. The inosine base alters dsRNA structure to prevent aberrant activation of antiviral cytosolic helicase RIG-I-like receptors. We review how effects of inosines, ADARs, and other modi-fied bases have been shown to be important in innate immunity and cancer.

引用

页码：758 / 771

页数：14

共 96 条

[1] Regulation of cGAS- and RLR-mediated immunity to nucleic acids [J].

Ablasser, Andrea ;

Hur, Sun .

NATURE IMMUNOLOGY, 2020, 21 (01) :17-29

[2] Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation [J].

Ahmad, Sadeem ;

Mu, Xin ;

Yang, Fei ;

Greenwald, Emily ;

Park, Ji Woo ;

Jacob, Etai ;

Zhang, Cheng-Zhong ;

Hur, Sun .

CELL, 2018, 172 (04) :797-+

[3] A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes [J].

Bazak, Lily ;

Haviv, Ami ;

Barak, Michal ;

Jacob-Hirsch, Jasmine ;

Deng, Patricia ;

Zhang, Rui ;

Isaacs, Farren J. ;

Rechavi, Gideon ;

Li, Jin Billy ;

Eisenberg, Eli ;

Levanon, Erez Y. .

GENOME RESEARCH, 2014, 24 (03) :365-376

[4] Identification of the long, edited dsRNAome of LPS-stimulated immune cells [J].

Blango, Matthew G. ;

Bass, Brenda L. .

GENOME RESEARCH, 2016, 26 (06) :852-862

[5] MODOMICS: a database of RNA modification pathways. 2017 update [J].

Boccaletto, Pietro ;

Machnicka, Magdalena A. ;

Purta, Elzbieta ;

Piatkowski, Pawe ;

Baginski, Blazej ;

Wirecki, Tomasz K. ;

de Crecy-Lagard, Valerie ;

Ross, Robert ;

Limbach, Patrick A. ;

Kotter, Annika ;

Helm, Mark ;

Bujnicki, Janusz M. .

NUCLEIC ACIDS RESEARCH, 2018, 46 (D1) :D303-D307

[6] The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators [J].

Bou-Nader, Charles ;

Gordon, Jackson M. ;

Henderson, Frances E. ;

Zhang, Jinwei .

RNA, 2019, 25 (05) :539-556

[7] Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown [J].

Chung, Hachung ;

Calis, Jorg J. A. ;

Wu, Xianfang ;

Sun, Tony ;

Yu, Yingpu ;

Sarbanes, Stephanie L. ;

Viet Loan Dao Thi ;

Shilvock, Abigail R. ;

Hoffmann, H. -Heinrich ;

Rosenberg, Brad R. ;

Rice, Charles M. .

CELL, 2018, 172 (04) :811-+

[8]

Comabella M, 2009, ARCH NEUROL-CHICAGO, V66, P972, DOI 10.1001/archneurol.2009.150

[9] Cardiac valve involvement inADAR-related type I interferonopathy [J].

Crow, Yanick ;

Keshavan, Nandaki ;

Barbet, Jacques Patrick ;

Bercu, Geanina ;

Bondet, Vincent ;

Boussard, Charlotte ;

Dedieu, Nathalie ;

Duffy, Darragh ;

Hully, Marie ;

Giardini, Alessandro ;

Gitiaux, Cyril ;

Rice, Gillian Inara ;

Seabra, Luis ;

Bader-Meunier, Brigitte ;

Rahman, Shamima .

JOURNAL OF MEDICAL GENETICS, 2020, 57 (07) :475-478

[10] Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 [J].

Crow, Yanick J. ;

Chase, Diana S. ;

Schmidt, Johanna Lowenstein ;

Szynkiewicz, Marcin ;

Forte, Gabriella M. A. ;

Gornall, Hannah L. ;

Oojageer, Anthony ;

Anderson, Beverley ;

Pizzino, Amy ;

Helman, Guy ;

Abdel-Hamid, Mohamed S. ;

Abdel-Salam, Ghada M. ;

Ackroyd, Sam ;

Aeby, Alec ;

Agosta, Guillermo ;

Albin, Catherine ;

Allon-Shalev, Stavit ;

Arellano, Montse ;

Ariaudo, Giada ;

Aswani, Vijay ;

Babul-Hirji, Riyana ;

Baildam, Eileen M. ;

Bahi-Buisson, Nadia ;

Bailey, Kathryn M. ;

Barnerias, Christine ;

Barth, Magalie ;

Battini, Roberta ;

Beresford, Michael W. ;

Bernard, Genevieve ;

Bianchi, Marika ;

de Villemeur, Thierry Billette ;

Blair, Edward M. ;

Bloom, Miriam ;

Burlina, Alberto B. ;

Carpanelli, Maria Luisa ;

Carvalho, Daniel R. ;

Castro-Gago, Manuel ;

Cavallini, Anna ;

Cereda, Cristina ;

Chandler, Kate E. ;

Chitayat, David A. ;

Collins, Abigail E. ;

Sierra Corcoles, Concepcion ;

Cordeiro, Nuno J. V. ;

Crichiutti, Giovanni ;

Dabydeen, Lyvia ;

Dale, Russell C. ;

D'Arrigo, Stefano ;

De Goede, Christian G. E. L. ;

De Laet, Corinne .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2015, 167 (02) :296-312

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