The Current Status of the Production and Supply of Gallium-68

被引：38
作者：
Kumar, Krishan [1 ]
机构：
[1] Ohio State Univ, Dept Radiol, Lab Translat Res Imaging Pharmaceut, Wright Ctr Innovat Biomed Imaging, Columbus, OH 43212 USA
来源：
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2020年 / 35卷 / 03期
关键词：
Ga-68; Ge-68; generators; cyclotron produced Ga-68; liquid targets; production and supply; solid targets; CYCLOTRON PRODUCTION; FUTURE;
D O I：
10.1089/cbr.2019.3301
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gallium-68 (Ga-68) is an important radionuclide due to its successful use in the clinic. Currently, Ga-68 is produced and supplied by using germanium-68/Gallium-68 (Ge-68/Ga-68) generator systems in the preclinical and clinical environments. Until recently, the supply of Ge-68/Ga-68 generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of Ga-68 by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of Ga-68 radionuclide.
引用
收藏
页码：163 / 166
页数：4
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