Prognostic significance of body mass index in patients with localized renal cell carcinoma

被引:0
作者
Wang, Chengtao [1 ]
Chen, Zebin [2 ]
Dong, Jun [1 ]
Wen, Bixiu [1 ]
Fang, Yong [2 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou 510080, Guangdong, Peoples R China
来源
INTERNATIONAL BRAZ J UROL | 2018年 / 44卷 / 06期
关键词
Body Mass Index; Carcinoma; Renal Cell; Prognosis; CANCER-PATIENTS; HEART-FAILURE; RISK-FACTORS; SURVIVAL; OBESITY; IMPACT; OVERWEIGHT; CLASSIFICATION; COMPLICATIONS; SMOKING;
D O I
10.1590/S1677-5538.IBJU.2017.0629
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate the relationship between the pretreatment body mass index (BMI) and the clinical outcomes in patients with localized stage I - III renal cell carcinoma (RCC) surgically treated. Materials and Methods: From January 2000 to December 2012, 798 patients with stage I - III RCC were recruited from First Affiliated Hospital and Cancer Center of Sun Yat - Sen University. Patients were divided into two groups of BMI < 25 kg / m2 or BMI >= 25 kg / m2 according to the World Health Organization classifications for Asian populations. The differences in the long-term survival of these two BM1 groups were analyzed. Results: The 5 - year failure - free survival rates for BMI < 25 kg / m2 and BMI >= 25 kg / m2 groups were 81.3% and 93.3%, respectively (P = 0.002), and the 5 - year overall survival rates were 82.5% and 93.8%, respectively (P = 0.003). BMI was a favored prognostic factor of overall survival and failure - free survival in a Cox regression model. Conclusions: Pretreatment body mass index was an independent prognostic factor for Chinese patients surgically treated, localized stage I - III RCC.
引用
收藏
页码:1147 / 1155
页数:9
相关论文
共 43 条
[1]   Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies [J].
Barba, C ;
Cavalli-Sforza, T ;
Cutter, J ;
Darnton-Hill, I ;
Deurenberg, P ;
Deurenberg-Yap, M ;
Gill, T ;
James, P ;
Ko, G ;
Miu, AH ;
Kosulwat, V ;
Kumanyika, S ;
Kurpad, A ;
Mascie-Taylor, N ;
Moon, HK ;
Nishida, C ;
Noor, MI ;
Reddy, KS ;
Rush, E ;
Schultz, JT ;
Seidell, J ;
Stevens, J ;
Swinburn, B ;
Tan, K ;
Weisell, R ;
Wu, ZS ;
Yajnik, CS ;
Yoshiike, N ;
Zimmet, P .
LANCET, 2004, 363 (9403) :157-163
[2]   Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].
Calle, EE ;
Kaaks, R .
NATURE REVIEWS CANCER, 2004, 4 (08) :579-591
[3]   Body mass index and survival in patients with renal cell carcinoma: A clinical-based cohort and meta-analysis [J].
Choi, Yuni ;
Park, Bumsoo ;
Jeong, Byong Chang ;
Seo, Seong Il ;
Jeon, Seong Soo ;
Choi, Han Yong ;
Adami, Hans-Olov ;
Lee, Jung Eun ;
Lee, Hyun Moo .
INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (03) :625-634
[4]   Obesity, hypertension, and the risk of kidney cancer in men. [J].
Chow, WH ;
Gridley, G ;
Fraumeni, JF ;
Jarvholm, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (18) :1305-1311
[5]   Renal-cell carcinoma [J].
Cohen, HT ;
McGovern, FJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2477-2490
[6]   Renal cell cancer and body size at different ages: An Italian multicenter case-control study [J].
Dal Maso, Luigino ;
Zucchetto, Antonella ;
Tavani, Alessandra ;
Montella, Maurizio ;
Ramazzotti, Valerio ;
Talamini, Renato ;
Canzonieri, Vincenzo ;
Garbeglio, Antonio ;
Negri, Eva ;
Tonini, Annamaria ;
La Vecchia, Carlo ;
Franceschi, Silvia .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (05) :582-591
[7]   Body mass and survival in patients with chronic heart failure without cachexia: The importance of obesity [J].
Davos, CH ;
Doehner, W ;
Rauchhaus, M ;
Cicoira, M ;
Francis, DP ;
Coats, AJS ;
Clark, AL ;
Anker, SD .
JOURNAL OF CARDIAC FAILURE, 2003, 9 (01) :29-35
[8]   Prognostic value of body mass index in locally advanced breast cancer [J].
Dawood, Shaheenah ;
Broglio, Kristine ;
Gonzalez-Angulo, Ana M. ;
Kau, Shu-Wan ;
Islam, Rabiul ;
Hortobagyi, Gabriel N. ;
Cristofanilli, Massimo .
CLINICAL CANCER RESEARCH, 2008, 14 (06) :1718-1725
[9]   Histologic Variants of Renal Cell Carcinoma: Does Tumor Type Influence Outcome? [J].
Deng, Fang-Ming ;
Melamed, Jonathan .
UROLOGIC CLINICS OF NORTH AMERICA, 2012, 39 (02) :119-+
[10]   Impact of body mass index on survival of patients with surgically treated renal cell carcinoma [J].
Donat, SM ;
Salzhauer, EW ;
Mitra, N ;
Yanke, BV ;
Snyder, ME ;
Russo, P .
JOURNAL OF UROLOGY, 2006, 175 (01) :46-52