A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

被引：19

作者：

Castellano, Sabrina ^{[2
]}

Bertamino, Alessia ^{[2
]}

Gomez-Monterrey, Isabel ^{[1
]}

Santoriello, Marisabella ^{[2
]}

Grieco, Paolo ^{[1
]}

Campiglia, Pietro ^{[2
]}

Sbardella, Gianluca ^{[2
]}

Novellino, Ettore ^{[1
]}

机构：

[1] Univ Naples Feder 2, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy

[2] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, Italy

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 04期

关键词：

michael addition; eco-friendly heterogeneous catalysts; quinone-containing antitumoral drugs;

D O I：

10.1016/j.tetlet.2007.11.148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for double Michael additions to quinone systems catalyzed by Al(2)O(3), is reported. The advantages of this method include the use of a cheap and environment-friendly catalyst, a straightforward isolation of the pure product by filtration, high yields, and excellent selectivity, thus providing rapid access to useful building blocks for the preparation of biologically active quinones. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：583 / 585

页数：3

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