Inductive heating of mg ferrite powder in high-water content phantoms using AC magnetic field for local hyperthermia

The purpose of this study is to elevate the temperature and induce necrosis tumor cells that include ferrite powder to 50-60 degrees C by applying an alternating magnetic field. The achieved temperature is higher when compared to the conventional hyperthermia methods. We performed an experiment in which a high-water content agar phantom that was used as a quasi-tissue had 50 nm-10 mu m magnesium ferrite (MgFe2O4) dispersed in it and was then heated to a level of 190-700 kHz. The results show that the temperature of the phantom is higher for higher frequencies, larger particle sizes, and higher quantities of dispersed ferrite powder. Also, taking into account heat generation due to the magnetic powder, heat generation due to tissue metabolism, and the cooling effect of the blood flow, we solved the thermal equation related to local thermal therapy. Small differences in the distribution of ferrite powder affect the temperature increase of the tissue and the area where cell necrosis is induced.