Fragmentation patterns of novel dithiocarbamate derivatives with pharmaceutical activity under electrospray ionization tandem mass spectrometry conditions

被引：2

作者：

Wang, Xin ^{[2
]}

Sha, Yaowu ^{[1
]}

Ge, Zemei ^{[2
]}

Wang, Wei ^{[2
]}

Li, Runtao ^{[2
]}

机构：

[1] Tsinghua Univ, Dept Chem, Sch Life Sci & Engn, Minist Educ,Key Lab Bioorgan Phosphorus Chem, Beijing 100084, Peoples R China

[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2011年 / 25卷 / 02期

关键词：

ACID-ESTERS; DITIOCARB;

D O I：

10.1002/rcm.4847

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The fragmentation patterns of a novel series of dithiocarbamate derivatives with pharmaceutical activity were investigated by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry (ESI-MSn). In the gas phase, the dithiocarbamate protonated molecules containing the piperazinium moiety undergo losses of bromide to form the piperazinium cation by ionization, followed by subsequent losses of methyl bromide, ring opening and rearrangement of piperazinium. Furthermore, the dithiocarbamate derivatives and their intermediates both undergo cleavage of the C-S bond to produce two common fragment ions. The different fragmentation observed for these compounds facilitated their identification and could be valuable in the further study of their metabolic pathways as prodrugs. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：349 / 354

页数：6