IL-18 and IL-18 binding protein levels in patients with dengue virus infection

被引：0
作者：
Chirathaworn, Chintana [1 ]
Poovorawan, Yong [2 ]
Vuthitanachot, Viboonsak
机构：
[1] Chulalongkorn Univ, Fac Med, Dept Microbiol, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Med, Dept Pediat, Bangkok 10330, Thailand
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2010年 / 3卷 / 10期
关键词：
Dengue virus; IL-18; IL-18BP; HEMORRHAGIC-FEVER; ENDOTHELIAL-CELLS; CYTOKINE; INTERLEUKIN-18; ACTIVATION;
D O I：
10.1016/S1995-7645(10)60195-2
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To determine the levels of IL-18 and IL-18 binding protein(BP) in patients with dengue virus infection. Methods: Acute and convalescent sera were collected from each patient. :Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays. Results: It was shown that IL-18 and IL-18BP levels were significantly higher in patients when compared with controls. In addition, the level of IL-18BP was lower in convalescent than in acute sera. Conclusions: These data suggest that both IL-18 and IL-18BP production was induced following dengue virus infection. Investigating the regulation of IL-18 by its natural regulator could lead to further understanding of the immune response or immunopathogenesis following dengue virus infection.
引用
收藏
页码：812 / 814
页数：3
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