Aberrant branched-chain amino acid catabolism in cardiovascular diseases

被引：18

作者：

Xiong, Yixiao ^{[1
,2
]}

Jiang, Ling ^{[1
,2
]}

Li, Tao ^{[1
,2
]}

机构：

[1] Sichuan Univ, Natl Local Joint Engn Res Ctr Translat Med Anesthe, Dept Anesthesiol, West China Hosp, Chengdu, Peoples R China

[2] Sichuan Univ, Lab Mitochondria & Metab, West China Hosp, Chengdu, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

branched-chain amino acids; catabolism; cardiovascular diseases; heart failure; coronary artery disease; CORONARY-ARTERY-DISEASE; PRESERVED EJECTION FRACTION; INSULIN-RESISTANCE; HEART-FAILURE; DILATED CARDIOMYOPATHY; PYRUVATE-DEHYDROGENASE; ALPHA-KETOISOCAPROATE; CARDIAC DYSFUNCTION; ISOENZYME PATTERNS; ADIPOSE-TISSUE;

D O I：

10.3389/fcvm.2022.965899

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Globally, cardiovascular diseases are the leading cause of death. Research has focused on the metabolism of carbohydrates, fatty acids, and amino acids to improve the prognosis of cardiovascular diseases. There are three types of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) required for protein homeostasis, energy balance, and signaling pathways. Increasing evidence has implicated BCAAs in the pathogenesis of multiple cardiovascular diseases. This review summarizes the biological origin, signal transduction pathways and function of BCAAs as well as their significance in cardiovascular diseases, including myocardial hypertrophy, heart failure, coronary artery disease, diabetic cardiomyopathy, dilated cardiomyopathy, arrhythmia and hypertension.

引用

页数：10

共 117 条

[1] Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support [J].

Ahmad, Tariq ;

Kelly, Jacob P. ;

McGarrah, Robert W. ;

Hellkamp, Anne S. ;

Fiuzat, Mona ;

Testani, Jeffrey M. ;

Wang, Teresa S. ;

Verma, Amanda ;

Samsky, Marc D. ;

Donahue, Mark P. ;

Ilkayeva, Olga R. ;

Bowles, Dawn E. ;

Patel, Chetan B. ;

Milano, Carmelo A. ;

Rogers, Joseph G. ;

Felker, G. Michael ;

O'Connor, Christopher M. ;

Shah, Svati H. ;

Kraus, William E. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (03) :291-299

[2] SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion [J].

Anderson, Kristin A. ;

Huynh, Frank K. ;

Fisher-Wellman, Kelsey ;

Stuart, J. Darren ;

Peterson, Brett S. ;

Douros, Jonathan D. ;

Wagner, Gregory R. ;

Thompson, J. Will ;

Madsen, Andreas S. ;

Green, Michelle F. ;

Sivley, R. Michael ;

Ilkayeva, Olga R. ;

Stevens, Robert D. ;

Backos, Donald S. ;

Capra, John A. ;

Olsen, Christian A. ;

Campbell, Jonathan E. ;

Muoio, Deborah M. ;

Grimsrud, Paul A. ;

Hirschey, Matthew D. .

CELL METABOLISM, 2017, 25 (04) :838-+

[3] Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction [J].

Ather, Sameer ;

Chan, Wenyaw ;

Bozkurt, Biykem ;

Aguilar, David ;

Ramasubbu, Kumudha ;

Zachariah, Amit A. ;

Wehrens, Xander H. T. ;

Deswal, Anita .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (11) :998-1005

[4] Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells [J].

Azizi, Paymon M. ;

Zyla, Roman E. ;

Guan, Sha ;

Wang, Changsen ;

Liu, Jun ;

Bolz, Steffen-Sebastian ;

Heit, Bryan ;

Klip, Amira ;

Lee, Warren L. .

MOLECULAR BIOLOGY OF THE CELL, 2015, 26 (04) :740-750

[5] Serum and Adipose Tissue Amino Acid Homeostasis in the Metabolically Healthy Obese [J].

Badoud, Flavia ;

Lam, Karen P. ;

DiBattista, Alicia ;

Perreault, Maude ;

Zulyniak, Michael A. ;

Cattrysse, Bradley ;

Stephenson, Susan ;

Britz-McKibbin, Philip ;

Mutch, David M. .

JOURNAL OF PROTEOME RESEARCH, 2014, 13 (07) :3455-3466

[6] Effects of different branched-chain amino acids supplementation protocols on the inflammatory response of LPS-stimulated RAW 264.7 macrophages [J].

Bonvini, Andrea ;

Rogero, Marcelo Macedo ;

Coqueiro, Audrey Yule ;

Raizel, Raquel ;

Bella, Leonardo Mendes ;

Fock, Ricardo Ambrosio ;

Borelli, Primavera ;

Tirapegui, Julio .

AMINO ACIDS, 2021, 53 (04) :597-607

[7] From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study [J].

Buondonno, Ilaria ;

Sassi, Francesca ;

Carignano, Giulia ;

Dutto, Francesca ;

Ferreri, Cinzia ;

Pili, Fausto G. ;

Massaia, Massimiliano ;

Nisoli, Enzo ;

Ruocco, Chiara ;

Porrino, Paola ;

Ravetta, Claudia ;

Riganti, Chiara ;

Isaia, Giovanni C. ;

D'Amelio, Patrizia .

CLINICAL NUTRITION, 2020, 39 (07) :2080-2091

[8] Autophagy and Inflammasome Activation in Dilated Cardiomyopathy [J].

Caragnano, Angela ;

Aleksova, Aneta ;

Bulfoni, Michela ;

Cervellin, Celeste ;

Rolle, Irene Giulia ;

Veneziano, Claudia ;

Barchiesi, Arianna ;

Mimmi, Maria Chiara ;

Vascotto, Carlo ;

Finato, Nicoletta ;

Sponga, Sandro ;

Livi, Ugolino ;

Isola, Miriam ;

Di Loreto, Carla ;

Bussani, Rossana ;

Sinagra, Gianfranco ;

Cesselli, Daniela ;

Beltrami, Antonio Paolo .

JOURNAL OF CLINICAL MEDICINE, 2019, 8 (10)

[9] SAR1B senses leucine levels to regulate mTORC1 signalling [J].

Chen, Jie ;

Ou, Yuhui ;

Luo, Rong ;

Wang, Jie ;

Wang, Dong ;

Guan, Jialiang ;

Li, Yi ;

Xia, Peixue ;

Chen, Peng R. ;

Liu, Ying .

NATURE, 2021, 596 (7871) :281-+

[10] Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure [J].

Chen, Mengping ;

Gao, Chen ;

Yu, Jiayu ;

Ren, Shuxun ;

Wang, Menglong ;

Wynn, Max ;

Chuang, David T. ;

Wang, Yibin ;

Sun, Haipeng .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 8 (11)

← 1 2 3 4 5 6 7 8 9 10 →