Aberrant branched-chain amino acid catabolism in cardiovascular diseases

被引：14
作者：
Xiong, Yixiao [1 ,2 ]
Jiang, Ling [1 ,2 ]
Li, Tao [1 ,2 ]
机构：
[1] Sichuan Univ, Natl Local Joint Engn Res Ctr Translat Med Anesthe, Dept Anesthesiol, West China Hosp, Chengdu, Peoples R China
[2] Sichuan Univ, Lab Mitochondria & Metab, West China Hosp, Chengdu, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷
基金：
中国国家自然科学基金;
关键词：
branched-chain amino acids; catabolism; cardiovascular diseases; heart failure; coronary artery disease; CORONARY-ARTERY-DISEASE; PRESERVED EJECTION FRACTION; INSULIN-RESISTANCE; HEART-FAILURE; DILATED CARDIOMYOPATHY; PYRUVATE-DEHYDROGENASE; ALPHA-KETOISOCAPROATE; CARDIAC DYSFUNCTION; ISOENZYME PATTERNS; ADIPOSE-TISSUE;
D O I：
10.3389/fcvm.2022.965899
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Globally, cardiovascular diseases are the leading cause of death. Research has focused on the metabolism of carbohydrates, fatty acids, and amino acids to improve the prognosis of cardiovascular diseases. There are three types of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) required for protein homeostasis, energy balance, and signaling pathways. Increasing evidence has implicated BCAAs in the pathogenesis of multiple cardiovascular diseases. This review summarizes the biological origin, signal transduction pathways and function of BCAAs as well as their significance in cardiovascular diseases, including myocardial hypertrophy, heart failure, coronary artery disease, diabetic cardiomyopathy, dilated cardiomyopathy, arrhythmia and hypertension.
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页数：10
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