Two New Alkaloids from Polyalthia nemoralis

被引：0

作者：

Nguyen Thi Tu Oanh ^{[1
]}

To Hai Tung ^{[1
]}

Cao Thi Hue ^{[1
]}

Le Nguyen Thanh ^{[1
]}

Do Thi Thao ^{[2
]}

Nguyen Thi Minh Hang ^{[1
]}

机构：

[1] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet Rd, Hanoi, Vietnam

[2] VAST, Inst Biotechnol, 18 Hoang Quoc Viet Rd, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 07期

关键词：

Polyalthia nemoralis; 8,9-Dimethoxysampangine; 7-Methoxy-8-hydroxyeupolauridine; Cytotoxicity; EUPOLAURIDINE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new azaoxoaporphine alkaloid, 8,9-dimethoxysampangine (1), and a new naphthyridine alkaloid, 7-methoxy-8-hydroxyeupolauridine (2), along with two known azaoxoaporphine alkaloids, sampangine (3) and 9-methoxysampangine (4), were isolated from the EtOAc extract of the barks of Polyalthia nemoralis. Their structures were established on the basis of spectral evidences. Compound 1 exhibited significant cytotoxicity against KB, MCF7, LU-1, HepG2, LNCap, SW626 and SW480 cancer cell lines with IC50 values in the range of 5.06 +/- 0.04 -7.61 +/- 0.06 mu M.

引用

页码：1025 / 1027

页数：3

共 9 条

[1] CONSTITUENTS OF EUPOMATIA SPECIES .4. STRUCTURE AND SYNTHESIS OF EUPOLAURIDINE (EL BASE-1) AND SOME OBSERVATIONS ON STRUCTURES OF EUPOLAURAMINE (EL BASE-2) AND HYDROXYEUPOLAURAMINE (EL BASE-3) [J].

BOWDEN, BF ;

PICKER, K ;

RITCHIE, E ;

TAYLOR, WC .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1975, 28 (12) :2681-2701

[2]

Bracher F, 1989, LIEBIGS ANN CHEM, V1989, P87

[3]

Hooker JD., 1875, FLORA BRIT INDIA, V1, P62

[4] ANTICANDIDAL ACTIVITY OF EUPOLAURIDINE AND ONYCHINE, ALKALOIDS FROM CLEISTOPHOLIS-PATENS [J].

HUFFORD, CD ;

LIU, S ;

CLARK, AM ;

OGUNTIMEIN, BO .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (05) :961-964

[5]

Leboeuf M, 1977, LLOYDIA, V39, P459

[6] Four new alkaloids from Polyalthia nemoralis (Annonaceae) [J].

Lu, Zi-Ming ;

Zhang, Qing-Jian ;

Chen, Ruo-Yun ;

Yu, De-Quan .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (07) :656-664

[7] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[8] Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha [J].

Muhammad, I ;

Dunbar, DC ;

Takamatsu, S ;

Walker, LA ;

Clark, AM .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05) :559-562

[9] SAMPANGINE, A NEW ALKALOID FROM CANANGA-ODORATA [J].

RAO, JUM ;

GIRI, GS ;

HANUMAIAH, T ;

RAO, KVJ .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (02) :346-347

← 1 →