A new antitubercular mulinane diterpenoid from Azorella madreporica Clos

被引：54
作者：
Wächter, GA
Franzblau, SG
Montenegro, G
Suarez, E
Fortunato, RH
Saavedra, E
Timmermann, BN [1 ]
机构：
[1] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
[2] Gillis W Long Hansens Dis Ctr, Lab Res Branch, Pharmacol Res Dept, Baton Rouge, LA 70894 USA
[3] Inst Nacl Tecnol Agropecuaria, Buenos Aires, DF, Argentina
[4] Pontificia Univ Catolica Chile, Dept Ecol, Santiago, Chile
[5] Univ Nacl Patagonia San Juan Bosco, Comodoro Rivadavia, Chubut, Argentina
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 07期
关键词：
D O I：
10.1021/np980066w
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioactivity-guided fractionation of the petroleum ether extract of Azorella madreporica Clos has led to the isolation of the novel, antitubercular mulinane diterpenoid 1. The structure has been elucidated on the basis of its 1D and 2D NMR spectra and by comparison with mulinolic acid 2 and a dehydration product 3 obtained from 1. The MIC of 1 for growth inhibition of the H(37)Rv Strain of Mycobacterium tuberculosis' was determined as 20 mu g/mL. LC-MS and NMR have suggested the presence of this new compound in four other species of Azorella.
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页码：965 / 968
页数：4
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