Biocompatibility of poly(carbonate urethane)s with various degrees of nanophase separation

被引：30

作者：

Hsu, SH ^{[1
]}

Kao, YC ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem Engn, Taichung, Taiwan

来源：

MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 03期

关键词：

bacterial adhesion; monocyte activation; nanophase separation; phase separation; platelet activation; platelet adhesion poly(carbonate urethane);

D O I：

10.1002/mabi.200400163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanophase separation has been suggested to influence the biological performance of polyurethane. In a previous work (Macromol. Biosci. 2004, 4 891), six different 4,4'-diphenylmethane diisocyanate (MDI)-based poly(carbonate urethane)s (PCUs) that exhibited various degrees of nanophase separation were synthesized and characterized. In the present work, these PCUs were used as a model system to study the effect of nanometric structures on the biocompatibility of polyurethane. Human blood platelet activation, monocyte activation, protein adsorption, and bacterial adhesion on PCU were investigated in vitro. It was found that human I, blood platelets as well as monocytes were less activated on the PCU surfaces with a greater degree of nanophase separation in general. This phenomenon was closely associated with the lower ratio of human fibrinogen/albumin competitively adsorbed on these surfaces. Bacterial adhesion was also inhibited in some nanophase-separated PCUs. (GRAPHIC) The morphology of a platelet on a PCU studied here.

引用

页码：246 / 253

页数：8

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