New method for the preparation of solid-phase bound isocyanocarboxylic acids and Ugi reactions therewith

被引：16
作者：
Henkel, B
Sax, M
Dömling, A
机构：
[1] Morphochem AG, D-81379 Munich, Germany
[2] Univ Munster, Inst Med & Pharmazeut Chem, D-48149 Munster, Germany
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 37期
关键词：
solid-phase synthesis; multicomponent reaction; Ugi-reaction; isocyanocarboxylic acid;
D O I：
10.1016/S0040-4039(03)01793-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method of synthesizing solid-phase bound isocyanocarboxylic acids is reported. The potassium salts of four different isocyanocarboxylic acids are coupled onto a brominated resin in DMF in good yields. 32 Ugi reactions were performed using these resins and 24 products were obtained in good to viable purities. (C) 2603 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7015 / 7018
页数：4
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