Unexpected facile sequential halolactamization-hydroxylation of 2,3-allenamides with CuX2 for the efficient synthesis of 4-halo-5-hydroxypyrrol-2(5H)-ones

被引：62
作者：
Ma, SM [1 ]
Xie, HX [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 24期
关键词：
D O I：
10.1021/ol006504j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] 4-Halo-5-hydroxypyrrol-2(5H)-ones were synthesized from the efficient sequential halolactamization-hydroxylation reaction of 4-monosubstituted 2,3-allenamides with CuX2 (X = Br, CI) in high yields. Halolactamization of fully substituted 2,3-dienamide (1f) afforded 4-halo-pyrrol-2(5H)-ones.
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页码：3801 / 3803
页数：3
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