Survival and overall treatment time after postoperative radio( chemo) therapy in patients with head and neck cancer

被引:38
|
作者
Tribius, Silke [1 ]
Donner, Johanna [1 ]
Pazdyka, Henning [1 ]
Muenscher, Adrian [2 ]
Groebe, Alexander [3 ]
Petersen, Cordula [1 ]
Kruell, Andreas [1 ]
Tennstedt, Pierre [4 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Radiat Oncol, Martinistr 52, D-20246 Hamburg, Germany
[2] Univ Med Ctr Hamburg Eppendorf, Dept Otorhinolaryngol & Head & Neck Surg, Hamburg, Germany
[3] Univ Med Ctr Hamburg Eppendorf, Dept Maxillofacial Surg, Hamburg, Germany
[4] Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 07期
关键词
overall treatment time; locally advanced head and neck cancer; adjuvant radiochemotherapy; survival; disease-free survival; PROGRESSION-FREE SURVIVAL; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; RADIATION-THERAPY; CHEMOTHERAPY TRIALS; RADIOTHERAPY; SURGERY; SURROGATE; INTERVAL; EORTC;
D O I
10.1002/hed.24407
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. Generally, overall treatment time for patients with locally advanced head and neck cancer should be as short as reasonably possible. This analysis was undertaken to determine at what overall treatment time additional survival/locoregional control benefits could be achieved compared to a 100-day cutoff. Methods. Clinical impact of overall treatment time was assessed in 272 patients by multivariable Cox regression and Kaplan-Meier analyses using the historical 100-day cutoff and the optimal overall treatment time, determined using recursive partitioning analysis. Survival endpoints were determined for the 100-day and optimal overall treatment times validated using bootstrap resampling. Results. Recursive partitioning determined the optimal overall treatment time as 87 days. In the 87-day multivariable analysis, adverse factors for overall survival (OS) and disease-free survival (DFS) were overall treatment time >= 87 days and extracapsular spread, and overall treatment time and R1 status, respectively. Conclusion. Overall treatment time is important for survival in patients with head and neck cancer. Completing treatment within as short a timeframe as possible may be associated with longer OS and DFS. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码:1058 / 1065
页数:8
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