Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig

被引：89

作者：

Rettenberger, G

Bruch, J

Fries, R

Archibald, AL

Hameister, H

机构：

[1] ETH ZURICH, DEPT ANIM SCI, CH-8092 ZURICH, SWITZERLAND

[2] ROSLIN INST, EDINBURGH EH25 9PS, MIDLOTHIAN, SCOTLAND

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 04期

关键词：

D O I：

10.1007/s003359900082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nineteen so-called type I-loci, including ACO2, ADRA2, CAST, CCK, CHAT, IGKC, IGLV, IL4 IL6, INHA, LIF, MX1, PTH, RBP2, TCRA, TCRB, TGFB2, TGFB3, and UOX have been mapped in the pig with an informative somatic cell hybrid panel. By analyzing these new assignments in the knowledge of heterologous chromosome painting (Zoo-FISH) data for the porcine genome, it is possible to predict subchromosomal locations for most of these loci. Previously defined regions of conserved synteny were confirmed, and the extent of six of these regions was refined. These improvements in the porcine gene map facilitate the transfer of gene mapping data from ''map-rich'' species such as humans and mice.

引用

页码：275 / 279

页数：5

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