Nanotechnology lights up the antitumor potency by combining chemotherapy with siRNA

被引：9
作者：
Sun, Jian [1 ]
Ogunnaike, Edikan Archibong [2 ]
Jiang, Xing [1 ]
Chen, Zhaowei [3 ,4 ]
机构：
[1] Nanjing Univ Chinese Med, Coll Nursing, Nanjing, Peoples R China
[2] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27515 USA
[3] Fuzhou Univ, Inst Food Safety & Environm Monitoring, Coll Chem, Fuzhou, Peoples R China
[4] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 36期
基金：
中国国家自然科学基金;
关键词：
TARGETED CO-DELIVERY; MESOPOROUS SILICA NANOPARTICLES; BREAST-CANCER; LUNG-CANCER; DRUG-DELIVERY; IN-VITRO; TUMOR MICROENVIRONMENT; SURVIVIN-SIRNA; VEGF SIRNA; MULTIFUNCTIONAL NANOPARTICLES;
D O I：
10.1039/d1tb01379c
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Nanotechnology-based combination anticancer therapy offers novel approaches to overcome the limitations of single-agent administration. The emerging siRNA technology combined with chemotherapy has shown considerable promise in anticancer therapy. There are three main challenges in the fabrication of siRNA/chemotherapeutic drug co-loaded nanovectors: adequate cargo protection, precise targeted delivery, and site-specific cargo release. This review presents a summary of the nanosystems that have recently been developed for co-delivering siRNA and chemotherapeutic drugs. Their combined therapeutic effects are also discussed.
引用
收藏
页码：7302 / 7317
页数：16
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